Neutrophil-derived MRP-14 is up-regulated in infectious osteomyelitis and stimulates osteoclast generation

Journal of Leukocyte Biology
Ulrike DapuntMatthias M Gaida

Abstract

Bone infections of patients with joint replacement by endoprosthesis (so called "periprosthetic joint infection") pose a severe problem in the field of orthopedic surgery. The diagnosis is often difficult, and treatment is, in most cases, complicated and prolonged. Patients often require an implant exchange surgery, as the persistent infection and the accompanying inflammation lead to tissue damage with bone degradation and consequently, to a loosening of the implant. To gain insight into the local inflammatory process, expression of the proinflammatory cytokine MRP-14, a major content of neutrophils, and its link to subsequent bone degradation was evaluated. We found MRP-14 prominently expressed in the affected tissue of patients with implant-associated infection, in close association with the chemokine CXCL8 and a dense infiltrate of neutrophils and macrophages. In addition, the number of MRP-14-positive cells correlated with the presence of bone-resorbing osteoclasts. MRP-14 plasma concentrations were significantly higher in patients with implant-associated infection compared with patients with sterile inflammation or healthy individuals, advocating MRP-14 as a novel diagnostic marker. A further biologic activity of MRP-14 w...Continue Reading

Citations

Jan 25, 2020·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Freja Lea LüthjeKerstin Skovgaard
Jan 31, 2018·Frontiers in Immunology·Chang XiaXiaoquan Rao
Jun 27, 2018·Frontiers in Immunology·Siwen WangJian Ma
May 18, 2016·Materials·Ulrike DapuntCarla Renata Arciola
Dec 17, 2020·Therapeutics and Clinical Risk Management·Ulrike DapuntYina Zhao

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