Neutrophil diversity and plasticity in tumour progression and therapy.

Nature Reviews. Cancer
Sebastien JaillonAlberto Mantovani

Abstract

Neutrophils play a key role in defence against infection and in the activation and regulation of innate and adaptive immunity. In cancer, tumour-associated neutrophils (TANs) have emerged as an important component of the tumour microenvironment. Here, they can exert dual functions. TANs can be part of tumour-promoting inflammation by driving angiogenesis, extracellular matrix remodelling, metastasis and immunosuppression. Conversely, neutrophils can also mediate antitumour responses by direct killing of tumour cells and by participating in cellular networks that mediate antitumour resistance. Neutrophil diversity and plasticity underlie the dual potential of TANs in the tumour microenvironment. Myeloid checkpoints as well as the tumour and tissue contexture shape neutrophil function in response to conventional therapies and immunotherapy. We surmise that neutrophils can provide tools to tailor current immunotherapy strategies and pave the way to myeloid cell-centred therapeutic strategies, which would be complementary to current approaches.

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Datasets Mentioned

BETA
GM-CSF

Methods Mentioned

BETA
electron microscopy
flow cytometry
scRNA-seq
biopsy

Clinical Trials Mentioned

NCT03400332
NCT03689699
NCT03177187
NCT01861054
NCT02001974
NCT02370238
NCT03161431
NCT03473925

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