PMID: 9543280May 16, 1998Paper

Neutrophil elastase: alpha-1-proteinase inhibitor complex in serum and bronchoalveolar lavage fluid in patients with pulmonary fibrosis

The European Respiratory Journal
H YamanouchiJ Takahara

Abstract

It was hypothesized that neutrophil elastase released from activated neutrophils may play an important role in the pathogenesis of pulmonary fibrosis. In the present study, we measured the neutrophil elastase:alpha-1-proteinase inhibitor complex (E-PI) in serum and bronchoalveolar lavage fluid (BALF) in 26 patients with pulmonary fibrosis and evaluated the correlation between E-PI levels and several parameters. E-PI levels in serum of patients with pulmonary fibrosis (635.8+/-112.0 ng.mL(-1)) were significantly elevated compared to normal nonsmokers (122.0+/-4.0 ng.mL(-1)) as well as normal smokers (132.8+/-8.4 ng.mL(-1)) (p<0.01). E-PI levels in serum significantly correlated with hepatocyte growth factor (HGF) levels in serum, C-reactive protein (CRP), and negatively correlated with arterial oxygen tension (Pa,O2), and arterial carbon dioxide tension (Pa,CO2). E-PI/albumin levels in BALF significantly correlated with HGF/albumin levels in BALF, lactate dehydrogenase (LDH)/albumin in BALF, total number of inflammatory cells (alveolar macrophages and neutrophils) in BALF, and several markers derived from epithelial cells in BALF. Our data demonstrated: 1) neutrophil elastase:alpha-1-proteinase inhibitor complex in serum increas...Continue Reading

Citations

Aug 17, 2000·Springer Seminars in Immunopathology·C FonsecaC M Black
Apr 20, 2014·PloS One·Angelia D LockettIrina Petrache
Apr 1, 2006·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Hee-Soon ImYeon-Sook Yun
Jun 13, 2014·International Journal of Chronic Obstructive Pulmonary Disease·Andrea PrimianiRichard L Kradin
Mar 21, 2007·Life Sciences·Sumako YoshiokaShigeru Kohno
Mar 1, 2008·Bioorganic & Medicinal Chemistry Letters·Michael P WintersBruce Tomczuk
Apr 12, 2003·Critical Care Medicine·Theo J MoraesGregory P Downey
Jan 13, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·K FredrikssonC M Skold
Mar 7, 2015·Journal of Leukocyte Biology·Alyssa D GregoryA McGarry Houghton
Jan 14, 2021·Cancer Metastasis Reviews·Kavita RawatAnju Shrivastava

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