Neutrophil Extracellular Traps Identification in Tegumentary Lesions of Patients with Paracoccidioidomycosis and Different Patterns of NETs Generation In Vitro

PLoS Neglected Tropical Diseases
Amanda Manoel Della ColettaLuciane Alarcão Dias-Melicio

Abstract

Paracoccidioidomycosis (PCM) is a systemic mycosis, endemic in most Latin American countries, especially in Brazil. It is caused by the thermo-dimorphic fungus of the genus Paracoccidioides (Paracoccidioides brasiliensis and Paracoccidioides lutzii). Innate immune response plays a crucial role in host defense against fungal infections, and neutrophils (PMNs) are able to combat microorganisms with three different mechanisms: phagocytosis, secretion of granular proteins, which have antimicrobial properties, and the most recent described mechanism called NETosis. This new process is characterized by the release of net-like structures called Neutrophil Extracellular Traps (NETs), which is composed of nuclear (decondensed DNA and histones) and granular material such as elastase. Several microorganisms have the ability of inducing NETs formation, including gram-positive and gram-negative bacteria, viruses and some fungi. We proposed to identify NETs in tegumentary lesions of patients with PCM and to analyze the interaction between two strains of P. brasiliensis and human PMNs by NETs formation in vitro. In this context, the presence of NETs in vivo was evidenced in tegumentary lesions of patients with PCM by confocal spectrum analyze...Continue Reading

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Citations

Sep 30, 2015·Immunobiology·Tatiana Fernanda BachiegaÂngela Maria Victoriano de Campos Soares
May 25, 2016·Annual Review of Phytopathology·Martha HawesZhongguo Xiong
Nov 8, 2017·Mycoses·Alexandre Giannecchini RomagnoloLuciane Alarcão Dias-Melicio
Jul 6, 2017·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Isabelle DurocherDenis Girard
Oct 12, 2017·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·R Ricci-AzevedoD Girard
Jan 12, 2021·Frontiers in Cellular and Infection Microbiology·Juan David Puerta-AriasÁngel González
Mar 2, 2021·Frontiers in Cellular and Infection Microbiology·Yohan Ricci ZontaLuciane Alarcão Dias-Melicio
Mar 9, 2021·Frontiers in Microbiology·Juliana da Costa SilvaRodrigo Tinoco Figueiredo
Jun 21, 2020·Microbial Pathogenesis·Carolina E Luna-RodríguezAlejandro Sánchez-González

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Methods Mentioned

BETA
density gradient centrifugation
phase contrast microscopy
biopsies
PMA
Confocal Microscopy
scanning electron microscopy
bronchoalveolar lavage

Software Mentioned

Pannoramic Viewer
Integrated Morphometry
ImageXpress
MetaXpress Custom Module Editor
GraphPad Prism
MetaXpress
Integrated

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