Neutrophil Extracellular Traps in Dengue Are Mainly Generated NOX-Independently.

Frontiers in Immunology
Fadel Muhammad GarishahQuirijn de Mast

Abstract

Neutrophil extracellular traps (NETs) are increasingly recognized to play a role in the pathogenesis of viral infections, including dengue. NETs can be formed NADPH oxidase (NOX)-dependently or NOX-independently. NOX-independent NETs can be induced by activated platelets and are very potent in activating the endothelium. Platelet activation with thrombocytopenia and endothelial dysfunction are prominent features of dengue virus infection. We postulated that dengue infection is associated with NOX-independent NET formation, which is related to platelet activation, endothelial perturbation and increased vascular permeability. Using our specific NET assays, we investigated the time course of NET formation in a cohort of Indonesian dengue patients. We found that plasma levels of NETs were profoundly elevated and that these NETs were predominantly NOX-independent NETs. During early recovery phase (7-13 days from fever onset), total NETs correlated negatively with platelet number and positively with platelet P-selectin expression, the binding of von Willebrand factor to platelets and levels of Syndecan-1. Patients with gall bladder wall thickening, an early marker of plasma leakage, had a higher median level of total NETs. Ex vivo, p...Continue Reading

References

Jun 28, 2011·The American Journal of Pathology·Teluguakula NarasarajuVincent T Chow
Sep 8, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mariana J Kaplan, Marko Radic
May 30, 2013·PLoS Neglected Tropical Diseases·Cornelia A M van de WegEsper G Kallas
Sep 7, 2013·Blood·Bryan G Yipp, Paul Kubes
Apr 4, 2014·Thrombosis and Haemostasis·M MichelsQ de Mast
May 17, 2015·Blood·Julia EtulainDenisa D Wagner
Oct 16, 2015·The Journal of Pathology·Bart CortjensReinout A Bem
Aug 19, 2016·Nature Reviews. Disease Primers·Maria G GuzmanScott B Halstead
Apr 30, 2017·The Journal of Infectious Diseases·Suhendro SuwartoMaulana Suryamin
May 13, 2017·Arteriosclerosis, Thrombosis, and Vascular Biology·Elmar PieterseJohan van der Vlag
May 26, 2017·PLoS Pathogens·Monique Ramos de Oliveira TrugilhoJonas Perales
Oct 11, 2017·Nature Reviews. Immunology·Venizelos Papayannopoulos
Jun 8, 2018·Mucosal Immunology·Fiona D BarrMarta Rodriguez-Garcia
Jun 16, 2018·Arteriosclerosis, Thrombosis, and Vascular Biology·Kashish ManchandaAnna Klinke
Jul 22, 2018·Biochemical and Biophysical Research Communications·Jamie E MeeganSarah Y Yuan
Sep 14, 2018·Nature Reviews. Rheumatology·Jessica McHugh
Feb 14, 2019·Blood·Mohamad Fadhli Bin MasriAshley L St John
Apr 18, 2019·Nature Communications·Milka KoupenovaJane E Freedman
Jun 12, 2019·Nature Microbiology·Jane P MessinaSimon I Hay
Oct 28, 2019·Cellular and Molecular Life Sciences : CMLS·Aneta Manda-HandzlikUrszula Demkow
Apr 21, 2020·Platelets·Marisol Perez-Toledo, Nonantzin Beristain-Covarrubias
Apr 22, 2020·ELife·Adela Constantinescu-BercuJames Tb Crawley
Jun 9, 2020·MedRxiv : the Preprint Server for Health Sciences·Yu ZuoYogendra Kanthi
Oct 27, 2020·Frontiers in Cellular and Infection Microbiology·Anamika SinghPrasenjit Guchhait

❮ Previous
Next ❯

Software Mentioned

GraphPad Prism
Studio
R

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne
Stephen M Smith
Image--the Journal of Nursing Scholarship
D Diers
Journal of Leukocyte Biology
Chuyi TanPing Wang
© 2021 Meta ULC. All rights reserved