Neutrophil extracellular traps in patients with pulmonary tuberculosis

Respiratory Research
Anne J van der MeerTom van der Poll

Abstract

Tuberculosis is a devastating infectious disease causing many deaths worldwide. Recent investigations have implicated neutrophil extracellular traps (NETs) in the host response to tuberculosis. The aim of the current study was to obtain evidence for NETs release in the circulation during human tuberculosis. For this we measured the plasma concentrations of nucleosomes in conjunction with neutrophil elastase, in 64 patients with active pulmonary tuberculosis and 32 healthy controls. Patients with active tuberculosis had elevated plasma levels of nucleosomes and elastase when compared with local healthy blood donors. Furthermore nucleosome and elastase levels showed a positive correlation. These findings provide the first evidence for the release of NETs in the circulation of patients with active pulmonary tuberculosis.

References

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Citations

Nov 1, 2018·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Davide ScozziAndrew E Gelman
Sep 19, 2019·Proteomics. Clinical Applications·Rakesh AryaRanjan Kumar Nanda
May 6, 2021·International Journal of Molecular Sciences·Rachana R BorkuteAnca Dorhoi
Jun 8, 2021·Frontiers in Immunology·Daniela E KirwanJon S Friedland

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Methods Mentioned

BETA
enzyme-linked immunosorbent assays
ELISA

Software Mentioned

GraphPad
GraphPad Prism

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