Neutrophil extracellular traps: The core player in vascular complications of diabetes mellitus

Diabetes & Metabolic Syndrome
Alexander Berezin

Abstract

Diabetes mellitus (DM) is the most important metabolic disease with major threat for public health and increased risk of premature death. The prevalence of DM steadily rises in developing and developed countries achieving the epidemic level. Manifestation and progression of DM corresponds to developing vasculopathies, such as retinopathy, micro- and macro angiopathies, which negatively influence on clinical outcomes and quality-of-life. Although there are remarkable differences in the prevalence of vasculopathy in various types of DM, hyperglycemia and lipotoxicity are discussed as a major factors contributing to vascular complications partly through inducing neutrophil extracellular trap (NET). The NET or NETosis is unique form of cell death, which is an important core component of innate immune system. The review is dedicated the role of NET as a link between endothelium, inflammation and thrombosis that is crucial for development of DM-induced vasculopathy. It has suggested that NET formation could be not just a target for the DM care, but also a biomarker for stratification of DM patients at higher risk of vascular complications.

Citations

Mar 4, 2020·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Tatsuhiko HirotaToshiaki Iba
May 1, 2020·Frontiers in Cardiovascular Medicine·Alexander E Berezin, Alexander A Berezin
Aug 3, 2020·Clinical Reviews in Allergy & Immunology·Victoria Mutua, Laurel J Gershwin
Aug 11, 2020·Mediators of Inflammation·Tiewei LiJunmei Yang
Jul 24, 2020·Journal of Thrombosis and Thrombolysis·Richard C Becker
Jan 13, 2021·International Journal of Molecular Sciences·Johannes KlopfChristoph Neumayer
May 20, 2020·Biochemical and Biophysical Research Communications·Sang-Jin KimJong-Wan Park
Apr 5, 2021·Veterinary Immunology and Immunopathology·Ershun ZhouZhengtao Yang
Jun 3, 2021·Biomedicines·Tommaso Gori
Mar 5, 2021·The Journal of Clinical Endocrinology and Metabolism·Sebastian HörberAndreas Peter
Aug 20, 2019·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·Da Young SongHyun Kyung Kim
Oct 3, 2020·Journal of Natural Products·Adelaide SousaMarisa Freitas

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