Abstract
Neutrophil gelatinase-associated lipocalin (NGAL) is an early marker of acute kidney injury (AKI). Urine NGAL and serum NGAL (sNGAL) were assessed at 2, 6, 24, and 48 hours after contrast media (CM) exposure in 458 high-risk patients (development set). Optimal thresholds in predicting contrast-induced AKI (serum creatinine [sCr] increase ≥0.3 mg/dL at 48 hours after CM administration) were identified. Major adverse events (MAE; death, dialysis, nonfatal myocardial infarction, sustained kidney injury, and myocardial revascularization) at 1 year were assessed. In the development set, optimal thresholds for contrast-induced AKI occurred at 6 hours for both urine NGAL (≥20 ng/mL; 97% negative predictive value and 27% positive predictive value) and sNGAL (≥179 ng/mL; 93% negative predictive value and 20% positive predictive value). Furthermore, sNGAL ≥179 ng/mL at 6 hours was an independent predictor of 1-year MAE. 1-year MAE occurred in 27/198 patients (13.5%) with sNGAL <179 ng/mL and sCr <0.3 mg/dL, in 57/193 (29.5%) patients with only sNGAL ≥179 ng/mL, and in 37/67 (55%) patients with sCr ≥0.3 mg/dL. In additional 253 patients (validation set), no patient with urine NGAL <20 ng/mL or sNGAL <179 ng/mL at 6 hours developed contras...Continue Reading
References
Oct 27, 1997·Genomics·J B Cowland, N Borregaard
Sep 30, 2003·Journal of the American Society of Nephrology : JASN·Jaya MishraPrasad Devarajan
May 20, 2004·JAMA : the Journal of the American Medical Association·Gregory J MertenThomas P Kennedy
Apr 7, 2005·Lancet·Jaya MishraPrasad Devarajan
Jun 15, 2006·American Journal of Nephrology·H Bachorzewska-GajewskaS Dobrzycki
Jun 16, 2006·Current Opinion in Nephrology and Hypertension·Kai M Schmidt-OttJonathan Barasch
Mar 3, 2007·Critical Care : the Official Journal of the Critical Care Forum·Ravindra L MehtaUNKNOWN Acute Kidney Injury Network
Aug 7, 2007·Critical Care : the Official Journal of the Critical Care Forum·Michael ZappitelliStuart L Goldstein
Sep 18, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Russel HirschPrasad Devarajan
Feb 22, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Patrick T MurrayAdeera Levin
Mar 14, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Michael BennettPrasad Devarajan
Apr 12, 2008·Journal of the American College of Cardiology·Peter A McCullough
Apr 26, 2008·Biometrical Journal. Biometrische Zeitschrift·Marcus D RuoppEnrique F Schisterman
May 13, 2008·European Heart Journal·Giulia RomanoGerolama Condorelli
Jun 4, 2008·Annals of Internal Medicine·Thomas L NickolasJonathan Barasch
Jul 25, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Gebhard WagenerH Thomas Lee
May 9, 2009·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Charles E ChambersUNKNOWN Society for Cardiovascular Angiography and Interventions
May 29, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Anja Haase-FielitzMichael Haase
Oct 24, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Michael HaaseUNKNOWN NGAL Meta-analysis Investigator Group
Jan 9, 2010·Clinical Journal of the American Society of Nephrology : CJASN·David R McIlroyH Thomas Lee
May 5, 2010·Circulation·Carlo BriguoriAntonio Colombo
Jan 18, 2011·Nature Medicine·Neal ParagasJonathan Barasch
Apr 23, 2011·Journal of the American College of Cardiology·Michael HaasePeter R Mertens
Aug 17, 2011·Circulation·Carlo BriguoriUNKNOWN REMEDIAL II Investigators
Aug 20, 2011·Journal of the American College of Cardiology·Hitinder S GurmUNKNOWN BMC2 (Blue Cross Blue Shield of Michigan Cardiovascular Consortium) Registry
Jan 14, 2012·Journal of the American College of Cardiology·Thomas L NickolasJonathan Barasch
Sep 6, 2013·The New England Journal of Medicine·Michael G ShlipakUNKNOWN CKD Prognosis Consortium
Oct 11, 2013·Kidney International·Patrick T MurrayUNKNOWN ADQI 10 workgroup
Citations
Sep 4, 2015·Circulation. Cardiovascular Interventions·Harold L Dauerman
Oct 4, 2018·Renal Failure·Huihui LiQiaoling Zhou
May 24, 2018·PloS One·Annunziata NuscaGermano Di Sciascio
Jan 28, 2017·Scientific Reports·Werner RibitschJoerg H Horina
Apr 3, 2020·PloS One·Yi HeJunxiang Chen
Aug 12, 2017·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Carlo BriguoriGerolama Condorelli
Mar 17, 2017·BMC Cardiovascular Disorders·Olga L BarbarashAnton G Kutikhin
Oct 27, 2017·QJM : Monthly Journal of the Association of Physicians·M ConnollyM Harbinson
Jan 25, 2020·Chinese Medical Journal·Zheng-Yu WangZhen-Chang Wang
May 16, 2020·International Journal of Nephrology·Justor BandaSaraladevi Naicker
Jun 20, 2020·International Urology and Nephrology·Magdalena ZdziechowskaJacek Rysz
Oct 28, 2019·Toxicology Letters·Chu-Ting ChenChun-Jen Huang
Dec 10, 2020·Journal of Cardiac Failure·Y U HoriuchiPatrick T Murray
May 29, 2021·Journal of the American College of Cardiology·Giuseppina RoscignoCarlo Briguori
Sep 17, 2021·Scandinavian Journal of Clinical and Laboratory Investigation·Umit GurayOzgul Ucar Elalmis