Neutrophil gelatinase-associated lipocalin and acute kidney injury in endovascular aneurysm repair or open aortic repair: a pilot study

Biochemia Medica
Benedetta RampoldiElena Costa

Abstract

Acute kidney injury (AKI) occurs frequently after abdominal aortic surgery and there is currently no effective marker able to detect early onset. The aim of this study is to evaluate the ability of neutrophil gelatinase-associated lipocalin (NGAL) to early identify the development of acute renal damage in patients undergoing endovascular aneurysm repair (EVAR) or open aortic repair (OAR). Serial samples of blood and urine were obtained from 25 patients undergoing both EVAR and OAR. Seven male subjects with AKI and 18 subjects with no-AKI (17 males, 1 female) were included in the study. We determined concentrations of serum creatinine (sCr) and urinary, serum and whole blood NGAL (uNGAL, sNGAL, bNGAL) collected at baseline, and after 4 and 18 hours. AKI was defined according to the RIFLE criteria (risk, injury, failure, loss of kidney function, and end-stage kidney disease): increase by 50% in sCr or reduction of at least 25% of estimated glomerular filtration rate (eGFR) from baseline. Seven patients developed AKI in the stage Risk. There was no significant difference in sNGAL concentrations in the AKI group as compared to no-AKI group. However, the uNGAL/uCreatinine ratio and bNGAL concentrations were significantly higher afte...Continue Reading

References

Aug 18, 2004·Critical Care : the Official Journal of the Critical Care Forum·Rinaldo BellomoUNKNOWN Acute Dialysis Quality Initiative workgroup
Oct 24, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Michael HaaseUNKNOWN NGAL Meta-analysis Investigator Group
Mar 9, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Jay L Koyner, Chirag R Parikh
Aug 16, 2015·Journal of Cardiothoracic and Vascular Anesthesia·Ryan BrinkmanDuane J Funk
Jun 12, 2016·Journal of Vascular Surgery·Claudio CastagnoPietro Rispoli
Jul 31, 2016·Acta Physiologica·E V SchrezenmeierK M Schmidt-Ott

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Methods Mentioned

BETA
Enzyme-Linked Immunosorbent Assay
ELISA

Software Mentioned

SPSS

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