Neutrophil gelatinase-associated lipocalin (NGAL) as a marker of kidney damage

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
Davide BolignanoMichele Buemi

Abstract

Neutrophil gelatinase-associated lipocalin (NGAL) is a protein belonging to the lipocalin superfamily initially found in activated neutrophils, in accordance with its role as an innate antibacterial factor. However, it subsequently was shown that many other types of cells, including in the kidney tubule, may produce NGAL in response to various injuries. The increase in NGAL production and release from tubular cells after harmful stimuli of various kinds may have self-defensive intent based on the activation of specific iron-dependent pathways, which in all probability also represent the mechanism through which NGAL promotes kidney growth and differentiation. NGAL levels predict the future appearance of acute kidney injury after treatments potentially detrimental to the kidney and even the acute worsening of unstable nephropathies. Furthermore, recent evidence also suggests that NGAL somehow may be involved in the pathophysiological process of chronic renal diseases, such as polycystic kidney disease and glomerulonephritis. NGAL levels clearly correlate with severity of renal impairment, probably expressing the degree of active damage underlying the chronic condition. For all these reasons, NGAL may become one of the most promis...Continue Reading

References

Aug 15, 1996·The Biochemical Journal·D R Flower
Oct 9, 1999·The American Journal of Pathology·J R LehesteT E Willnow
Apr 7, 2000·Journal of the American Society of Nephrology : JASN·Yoshiki MoritaSeiichi Matsuo
Nov 28, 2002·Molecular Cell·Jun YangJonathan Barasch
Sep 30, 2003·Journal of the American Society of Nephrology : JASN·Jaya MishraPrasad Devarajan
Dec 10, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jack B CowlandNiels Borregaard
May 18, 2004·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Erik I Christensen, Jakub Gburek
May 19, 2004·American Journal of Nephrology·Jaya MishraPrasad Devarajan
Dec 8, 2004·Journal of the American Society of Nephrology : JASN·Jaya MishraPrasad Devarajan
Jan 8, 2005·The Journal of Biological Chemistry·Jane A GwiraLloyd G Cantley
Feb 16, 2005·The Journal of Clinical Investigation·Kiyoshi MoriJonathan Barasch
Dec 27, 2005·Cell·Laxminarayana R DevireddyMichael R Green
Feb 1, 2006·Proceedings of the National Academy of Sciences of the United States of America·Thorsten BergerTak W Mak
Feb 10, 2006·American Journal of Physiology. Renal Physiology·Mirjan M van TimmerenHarry van Goor
Mar 11, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jaya MishraPrasad Devarajan
Jun 15, 2006·American Journal of Nephrology·H Bachorzewska-GajewskaS Dobrzycki
Jun 15, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Howard TrachtmanUNKNOWN Investigators of the HUS-SYNSORB Pk Multicenter Clinical Trial
Jul 11, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C R ParikhP Devarajan
Sep 5, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Hanna Bachorzewska-GajewskaSlawomir Dobrzycki
Oct 13, 2006·Journal of the American Society of Nephrology : JASN·Mauro AbbateGiuseppe Remuzzi
Oct 31, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Mark M MitsnefesPrasad Devarajan
Jan 19, 2007·Journal of the American Society of Nephrology : JASN·Kai M Schmidt-OttJonathan Barasch
Mar 16, 2007·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Hanlu DingWenda Gao
Jun 16, 2007·American Journal of Nephrology·Davide BolignanoMichele Buemi
Sep 18, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Russel HirschPrasad Devarajan
Sep 26, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Davide BolignanoMichele Buemi

❮ Previous
Next ❯

Citations

Jun 25, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Davide BolignanoMichele Buemi
Jun 8, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Martin SkottSøren Nielsen
May 6, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Robert G FassettJeff S Coombes
May 10, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Maryam NejatZoltán H Endre
Apr 25, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Carrie A SchinstockJohn C Lieske
Aug 19, 2011·Kidney & Blood Pressure Research·Martin KimmelMark Dominik Alscher
Jan 24, 2013·Therapeutic Advances in Chronic Disease·Evan Meszaros, Charles J Malemud
Jan 10, 2012·Critical Care : the Official Journal of the Critical Care Forum·Tobias BreidthardtChristian Mueller
Apr 22, 2010·Clinical Chemistry and Laboratory Medicine : CCLM·Constantinos GiaginisStamatios Theocharis
Nov 19, 2011·Journal of the American Society of Nephrology : JASN·Azrina Md RalibZoltan H Endre
Jul 31, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Cheuk-Chun SzetoPhilip Kam-Tao Li
Jan 30, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Davide BolignanoMichele Buemi
Oct 26, 2012·Journal of Geriatric Cardiology : JGC·Rajiv ChoudharyAlan S Maisel
Dec 24, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Katerina VlasakovaWarren E Glaab
Jun 27, 2012·Biomarkers in Medicine·Erik A B BuijsSaskia N de Wildt
Jul 17, 2014·Critical Care : the Official Journal of the Critical Care Forum·Davide Bolignano, Giuseppe Coppolino
Apr 24, 2014·The Journal of Endocrinology·Marina C MuñozFernando P Dominici
Apr 9, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·María Teresa Torres-SalidoJosep Ordi-Ros
Jan 17, 2014·Journal of Human Hypertension·U DerhaschnigB Jilma
Dec 18, 2013·Clinical and Experimental Nephrology·Fumihiko FuruyaTetsuro Kobayashi
Feb 28, 2009·Women's Health·Peter A McCullough, Kavitha M Chinnaiyan
Sep 27, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Pier Paolo BassareoGiuseppe Mercuro
Jan 6, 2016·Journal of Clinical Medicine·Anusha H TennakoonJyoji Yamate
Oct 21, 2009·Renal Failure·Davide BolignanoMichele Buemi
May 15, 2013·Scandinavian Journal of Clinical and Laboratory Investigation·Christoph LiebetrauMichael Weber
Dec 17, 2015·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Vanessa AbellaOreste Gualillo
Apr 29, 2015·Scandinavian Cardiovascular Journal : SCJ·Ioannis VentoulisHaralambos Karvounis
Jan 25, 2012·Scandinavian Journal of Clinical and Laboratory Investigation·Stine E NielsenPeter Rossing
Mar 20, 2012·Blood Pressure·Andrzej BlumczynskiJacek Zachwieja
Jun 8, 2012·Scandinavian Journal of Clinical and Laboratory Investigation·Stine S PedersenBente Jespersen
Dec 7, 2013·Scandinavian Journal of Clinical and Laboratory Investigation·Christoph LiebetrauHolger Nef
Jul 2, 2015·Nephrology·Laura-Nanna LohkampTimo Siepmann
Aug 19, 2015·Biochimica Et Biophysica Acta·Saverio CandidoJames A McCubrey
Feb 22, 2012·Immune Network·Ho KimKyoungho Suk
Feb 24, 2016·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Antonio LacquanitiAntonio David
Mar 5, 2013·Analytical Biochemistry·Qiaoqiao RuanSergey Y Tetin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

© 2022 Meta ULC. All rights reserved