Neutrophil-guided dosing of anthracycline-cyclophosphamide-containing chemotherapy in patients with breast cancer: a feasibility study

Medical Oncology
Jan C DroogerFelix E de Jongh

Abstract

The aim of this study was to investigate whether neutrophil-guided dose escalation of anthracycline-cyclophosphamide-containing chemotherapy (ACC) for breast cancer is feasible, in order to optimize outcome. Breast cancer patients planned for 3-weekly ACC were enrolled in this study. The first treatment cycle was administered in a standard BSA-adjusted dose. The absolute neutrophil count was measured at baseline and at day 8, 11 and 15 after administration of ACC. For patients with none or mild (CTC grade 0-2) neutropenia and no other dose-limiting toxicity, we performed a 10-25 % dose escalation of the second cycle with the opportunity to a further 10-25 % dose escalation of the third cycle. Thirty patients were treated in the adjuvant setting with either FE100C (n = 23) or AC (n = 4), or in the palliative setting with FAC (n = 3). Two out of 23 patients (9 %) treated with FEC did not develop grade 3-4 neutropenia after the first treatment cycle. Dose escalation was performed in these two patients (30 % in one and 15 % in the other patient). During dose escalation, there were no complications like febrile neutropenia. No patients treated with FAC or AC could be escalated, since all of them developed grade 3-4 neutropenia. We c...Continue Reading

References

Jan 1, 1991·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G FalksonH C Falkson
Jan 1, 1982·Cancer Chemotherapy and Pharmacology·A H CalvertK R Harrap
Jul 17, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M J Ratain
Jul 17, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H P GurneyG Farrell
May 10, 2000·Clinical Pharmacokinetics·A RousseauG Lachâtre
Sep 5, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F E de JonghA Sparreboom
Nov 13, 2003·British Journal of Cancer·D A CameronR C F Leonard
Jun 26, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Floris A de JongAlex Sparreboom
Apr 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jacques BonneterreIsabelle Chapelle-Marcillac
Dec 14, 2005·Cancer Letters·Floris A de JongRon H J Mathijssen
Nov 23, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Henri RochéBernard Asselain
Nov 20, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F CardosoUNKNOWN ESMO Guidelines Working Group
Aug 24, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E SenkusUNKNOWN ESMO Guidelines Working Group
Mar 26, 2014·Nature Reviews. Clinical Oncology·Ron H J MathijssenJaap Verweij

❮ Previous
Next ❯

Citations

Jul 23, 2019·Seminars in Cancer Biology·Shaheen Khan, David E Gerber

❮ Previous
Next ❯

Software Mentioned

ANCHOR

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.