Neutrophil impairment associated with iron therapy in hemodialysis patients with functional iron deficiency.

Journal of the American Society of Nephrology : JASN
S I PatrutaWalter H Hörl

Abstract

Hemodialysis patients treated with recombinant human erythropoietin (rhEPO) need adequate iron supplementation to avoid rhEPO hyporesponsiveness due to iron deficiency. Low serum ferritin reflects absolute iron deficiency, whereas normal or high ferritin values in combination with low transferrin saturation (< 20%) indicate functional iron deficiency. In this study, healthy subjects (group I) were compared with intravenous (i.v.) rhEPO-treated and i.v. iron-saccharate-treated regular hemodialysis patients that were subdivided into three groups as follows: patients with serum ferritin > 100 and < 350 micrograms/L (group II), patients with ferritin < 60 micrograms/L (group III), and patients with ferritin > 650 micrograms/L but transferrin saturation < 20% (group IV). Polymorphonuclear leukocyte (PMNL) parameters (phagocytosis, intracellular killing of bacteria, oxidative metabolism, glucose uptake, intracellular calcium) for each group were compared with those of multitransfused, iron-overloaded primary hematologic patients (group V) and those of patients suffering from hereditary hemochromatosis (group VI). Compared with PMNL obtained from healthy subjects (group I), group II hemodialysis patients showed mild inhibition of phag...Continue Reading

Citations

Oct 27, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·S FishbaneS K Mittal
Oct 27, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·P S LimB Kho
Mar 11, 2000·Current Opinion in Clinical Nutrition and Metabolic Care·J H Brock
Aug 17, 2000·The Journal of Infectious Diseases·S Cunningham-RundlesM De Sousa
Nov 10, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·A T SkoutelisH P Bassaris
Nov 10, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·J ParkkinenK Rosenlöf
Jun 11, 1999·Journal of the American Society of Nephrology : JASN·H XiaA J Collins
Sep 30, 2003·Journal of the American Society of Nephrology : JASN·Gürkan SengoelgeGere Sunder-Plassmann
Sep 7, 1999·Journal of the American Society of Nephrology : JASN·A BesarabJ Yee
Feb 9, 2000·Journal of the American Society of Nephrology : JASN·Clarice Kazue FujiharaRoberto Zatz
Mar 12, 1999·Journal of the American Society of Nephrology : JASN·J Z MaA J Collins
Dec 1, 2001·Clinical Therapeutics·J Q Hudson, T J Comstock
Mar 20, 1999·Kidney International. Supplement·J W Eschbach, J W Adamson
Mar 20, 1999·Kidney International. Supplement·A Vychytil, M Haag-Weber
Mar 20, 1999·Kidney International. Supplement·S I Patruta, W H Hörl
Feb 22, 2002·Journal of the American Society of Nephrology : JASN·Harold I FeldmanGerald Faich
Jun 28, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Richard A ZagerHaimanot Wasse
Jul 26, 2002·Artificial Organs·R Vanholder, R Peleman
Dec 3, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Jerry Yee, Anatole Besarab
Feb 18, 2003·Current Opinion in Nephrology and Hypertension·Orson W MoeMariusz Kielar
Jul 9, 2003·Kidney International·Robert DeicherWalter H Hörl
Sep 3, 2003·European Journal of Biochemistry·Brigitte SturmBarbara Scheiber-Mojdehkar
Mar 9, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Caterina CanaveseFabrizio Fop
Apr 20, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Geoffrey S TeehanBertrand L Jaber
Jun 18, 2004·Kidney International·Gürkan SengoelgeGere Sunder-Plassmann
Jul 1, 2004·Hemodialysis International·Geoffrey S TeehanBertrand L Jaber
Jan 3, 2021·Seminars in Cell & Developmental Biology·David HaschkaGünter Weiss
Oct 6, 2004·Seminars in Dialysis·Steven FishbaneAllen R Nissenson
Nov 13, 2004·The Journal of the Association of Nurses in AIDS Care : JANAC·Ellen ButenskyChristine Miaskowski
Sep 27, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Wendy L St PeterAllan J Collins
Apr 16, 2005·Clinical Science·Daniel D MelleyGregory J Quinlan
Nov 12, 2005·European Journal of Clinical Investigation·G Weiss, V R Gordeuk
Nov 12, 2005·European Journal of Clinical Investigation·G SengölgeG Sunder-Plassmann
Jun 11, 2002·Critical Care Clinics·Laura M Dember
May 11, 2005·Kidney International·Bertrand L Jaber
Jul 11, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Edwin Patino, Oleh Akchurin
Sep 15, 2005·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Igor TheurlGünter Weiss
Jan 14, 2005·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Gürkan SengoelgeWalter H Hörl
Jul 6, 2005·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Michael BergmanHanna Bessler

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.

Related Papers

Clinical Nephrology
G Sunder-Plassmann, Walter H Hörl
Drug Safety : an International Journal of Medical Toxicology and Drug Experience
G Sunder-Plassmann, Walter H Hörl
© 2022 Meta ULC. All rights reserved