Neutrophil-lymphocyte ratio across psychiatric diagnoses: An electronic health record investigation

MedRxiv : the Preprint Server for Health Sciences
A. Brinn, James Stone


Objectives: The main objective of this study was to compare neutrophil-lymphocyte ratio, a marker of systemic inflammation, between patients diagnosed with ICD-10 psychiatric disorders and control participants. Design: A cross-sectional methodology was employed to retrospectively analyse electronic health records and records derived from a national health survey. Setting: A secondary mental health care service consisting of four boroughs in South London. Participants: A diverse sample of 13,888 psychiatric patients extracted from South London and Maudsley electronic health records database and 3,920 control participants extracted from National Health and Nutrition Survey (2015-2016) were included in the study. Primary and secondary outcome measures: Primary: NLR levels in patients with mental health diagnoses, NLR between patients with different mental health diagnoses. Secondary: Relationship of NLR to length of hospitalisation and to mortality. Results: NLR was elevated compared to controls in patients with diagnoses including dementia, alcohol dependence, schizophrenia, bipolar affective disorder, depression, non-phobic anxiety disorders, and mild mental retardation (p < 0.05). NLR also correlated with age, antipsychotic use...Continue Reading

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