Neutrophil-lymphocyte ratio across psychiatric diagnoses: a cross-sectional study using electronic health records.

BMJ Open
A. Brinn, James Stone

Abstract

The main objective of this study was to compare neutrophil-lymphocyte ratio (NLR), a marker of systemic inflammation, between patients diagnosed with International Classification of Diseases 10th Revision (ICD-10) psychiatric disorders and control participants. A cross-sectional methodology was employed to retrospectively analyse electronic health records and records derived from a national health survey. A secondary mental healthcare service consisting of four boroughs in South London. A diverse sample of 13 888 psychiatric patients extracted from South London and Maudsley electronic health records database and 3920 control participants extracted from National Health and Nutrition Survey (2015-2016) were included in the study. Primary: NLR levels in patients with mental health diagnoses, NLR between patients with different mental health diagnoses. Secondary: relationship of NLR to length of hospitalisation and to mortality. NLR was elevated compared with controls in patients with diagnoses including dementia, alcohol dependence, schizophrenia, bipolar affective disorder, depression, non-phobic anxiety disorders and mild mental retardation (p<0.05). NLR also correlated with age, antipsychotic use and hypnotic use. NLR was found...Continue Reading

References

Mar 4, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·S LanquillonH Vedder
Jan 30, 2007·Journal of Psychopharmacology·James M StoneLyn S Pilowsky
Mar 14, 2007·International Review of Neurobiology·Olivier GuillinMarc Laruelle
Oct 19, 2007·PLoS Medicine·Jan P VandenbrouckeUNKNOWN STROBE Initiative
Oct 31, 2007·American Heart Journal·Patrick H GibsonGraham S Hillis
Feb 2, 2008·Cleveland Clinic Journal of Medicine·Bradley N GaynesMaurizio Fava
Jul 1, 2008·Trends in Pharmacological Sciences·Philip J Cowen
Mar 3, 2010·Archives of General Psychiatry·Floriana S LuppinoFrans G Zitman
Jun 30, 2010·The International Journal of Neuroscience·Felix-Martin Werner, Rafael Coveñas
Jul 31, 2010·Science·Greg Miller
Oct 12, 2010·Schizophrenia Bulletin·Bruce N Cuthbert, Thomas R Insel
Sep 20, 2011·Current Psychiatry Reports·Charles L Raison, Andrew H Miller
Jul 28, 2012·Schizophrenia Bulletin·H Christian Fibiger
Dec 25, 2012·Expert Review of Cardiovascular Therapy·Tariq BhatThomas Costantino
Jan 8, 2013·Journal of Clinical Laboratory Analysis·Mehmet CelikbilekMehmet Yücesoy
Mar 8, 2013·Depression and Anxiety·Andrew H MillerJennifer C Felger
Apr 4, 2013·Journal of Neuroinflammation·Souhel NajjarOrrin Devinsky
May 31, 2014·Journal of the National Cancer Institute·Arnoud J TempletonEitan Amir
Apr 2, 2015·Schizophrenia Bulletin·Valeria MondelliPaola Dazzan
Feb 16, 2016·Expert Review of Cardiovascular Therapy·Maxwell E Afari, Tariq Bhat
May 26, 2016·Current Topics in Behavioral Neurosciences·Lucile Capuron, Nathalie Castanon
Aug 23, 2016·Cellular & Molecular Immunology·Tsan Sam Xiao
May 10, 2017·Annual Review of Clinical Psychology·Peter Zachar, Kenneth S Kendler
Sep 28, 2017·International Journal of Rheumatic Diseases·S ChandrashekaraK Renuka
Oct 8, 2017·Neuroscience and Biobehavioral Reviews·Jairo Vinícius PintoOlavo B Amaral
Oct 17, 2017·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Yuchen WangMelchor Demetria
Mar 15, 2018·Progress in Neuro-psychopharmacology & Biological Psychiatry·Mario Gennaro MazzaMassimo Clerici
Sep 8, 2018·Frontiers in Psychiatry·Guillaume FondLaurent Boyer
Nov 19, 2018·Psychiatry Research·Matias Carvalho Aguiar MeloVeralice Meireles Sales de Bruin
Dec 24, 2018·Schizophrenia Research·Vasilios KarageorgiouIoannis Michopoulos
May 6, 2019·Brain, Behavior, and Immunity·A GialluisiUNKNOWN Moli-Sani Study Investigators

❮ Previous
Next ❯

Citations

Jun 17, 2021·Psychiatry Investigation·Aybeniz Civan KahveYunus Hacimusalar
Aug 27, 2021·Journal of Psychiatric Research·Vicent Llorca-BofíMaria Mur

❮ Previous
Next ❯

Software Mentioned

MASS
CRIS
R
Clinical Record Interactive Search ( CRIS )
SQL

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.

Related Papers

Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
S CedrésE Felip
Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
Hideaki ShimadaMatsuo Nagata
© 2021 Meta ULC. All rights reserved