Neutrophil-Lymphocyte Ratio and Pathological Response to Neoadjuvant Chemotherapy in Patients With Muscle-Invasive Bladder Cancer

Clinical Genitourinary Cancer
Jo-An SeahSrikala S Sridhar

Abstract

Cisplatin-based neoadjuvant chemotherapy (NC) improves overall survival in muscle-invasive bladder cancer (MIBC), but there are currently no predictive biomarkers of response to NC in MIBC. An increased peripheral blood neutrophil to lymphocyte ratio (NLR) is a marker of systemic inflammation and is linked to poor prognosis in some solid tumors. We evaluated whether NLR is associated with pathological response (pathR) in MIBC patients who receive NC. MIBC patients treated with NC and radical cystectomy (RC) between July 2006 and April 2013 were retrospectively reviewed. The primary end point was to find variables associated with pathR in the RC specimen after NC. Potential predictive markers were analyzed using logistic regression. NLR values before NC, midway through NC, and before RC were collected and compared between patients who achieved pathR ('responders') and those who did not ('nonresponders'). In 26 evaluable patients, age, sex, performance status, smoking status, stage, hydronephrosis, NLR before NC, midway through NC, and before RC were not significantly associated with pathR, but the pattern of NLR change between responders and nonresponders was significantly different (P = .038). Responders exhibited a sustained d...Continue Reading

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Citations

Aug 9, 2016·Clinical Oncology : a Journal of the Royal College of Radiologists·R Leibowitz-AmitR Berger
Sep 27, 2018·International Journal of Urology : Official Journal of the Japanese Urological Association·Yoshio Ohno
Sep 26, 2020·Frontiers in Oncology·Hyeong Dong Yuk, Ja Hyeon Ku
Dec 8, 2020·Cancer Science·Takashi KobayashiUNKNOWN Japan Urological Oncology Group
Apr 24, 2021·Urologic Oncology·Ekaterina LaukhtinaUNKNOWN European Association of Urology-Young Academic Urologists (EAU-YAU): Urothelial carcinoma working group

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