Neutrophil-lymphocyte ratio in patients with major depressive disorder undergoing no pharmacological therapy

Neuropsychiatric Disease and Treatment
Suleyman DemirAytekin Sır

Abstract

Studies attempting to clarify the relationship between major depressive disorder (MDD) and the immune system have been increasing in recent years. It was reported that increased production of the main proinflammatory cytokines, such as interleukin-1, interleukin-6, and tumor necrosis factor-alpha, and that of acute phase reactants may play a role in the etiopathogenesis of depression. Stress and depression were reported to increase leukocyte and neutrophil counts and to decrease lymphocyte count. Biological determinants affecting the diagnosis, therapy, and prognosis of depression are quite limited. Therefore, new etiological models are needed to explain the pathophysiology of depression. In recent years, neutrophil-lymphocyte ratio (NLR) was determined to be a good indicator of inflammatory status. There is no study in the literature investigating NLR in MDD. This study aims to examine the role of inflammation in the etiology of depression based on the NLR in MDD patients who are undergoing no pharmacological therapy. A total of 41 patients diagnosed with MDD, who received no antidepressant therapy within the past 1 month, were included in the study, which took place between January and March 2015. The control group consisted ...Continue Reading

Citations

Feb 27, 2019·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Mario Gennaro MazzaMassimo Clerici
Jun 6, 2019·Nordic Journal of Psychiatry·Nesrin KaramustafaliogluMurat Emul
Oct 13, 2021·Cellular and Molecular Neurobiology·Shusheng WuLongfei Du
Oct 26, 2021·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Serdar KaratoprakYunus Emre Dönmez

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