Neutrophil-lymphocyte ratio, monocyte-lymphocyte ratio and platelet-lymphocyte ratio in non-affective psychosis: A meta-analysis and systematic review.

The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry
Mario Gennaro MazzaMassimo Clerici

Abstract

Objectives: Neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and monocyte/lymphocyte ratio (MLR) are inexpensive and reproducible biomarkers of inflammation. This is the first meta-analysis exploring the role of NLR, MLR and PLR in non-affective psychosis.Methods: Eight studies have been identified from the main electronic databases. Meta-analyses based on random-effects models have been carried out generating pooled standardised mean differences (SMDs) between non-affective psychotic patients and healthy controls (HCs).Results: Subjects with non-affective psychosis had a significant higher NLR and MLR as compared with HC (respectively SMD = 0.715; P < 0.001; I2=57.565% and SMD = 0.417; P = 0.001; I2=65.754%), confirmed by heterogeneity-based sensitivity analysis. Subgroup analyses showed no differences in effect size across different study characteristics, including drug treatment status, diagnosis, and setting. Meta-regression showed that age influenced the relationship between non-affective psychosis and MLR. A trend of significance, not confirmed by heterogeneity-based sensitivity analysis, was observed in PLR with patients showing higher PLR than HC.Conclusions: Our meta-analysis supports the hypothesis t...Continue Reading

References

Jan 10, 2002·Brain, Behavior, and Immunity·M RothermundtT A Bayer
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Sep 23, 2003·Health Technology Assessment : HTA·J J DeeksUNKNOWN European Carotid Surgery Trial Collaborative Group
Aug 17, 2005·Current Drug Targets. Inflammation and Allergy·Tsuyoshi KasamaSteven L Kunkel
Feb 25, 2006·Nature Reviews. Immunology·Carl Nathan
Mar 4, 2006·The American Journal of Psychiatry·William W EatonPreben Bo Mortensen
Dec 26, 2006·Brain Research Reviews·W Y ChanP Rezaie
Jan 3, 2007·Archives of General Psychiatry·Jonna PeräläJouko Lönnqvist
Oct 31, 2007·American Heart Journal·Patrick H GibsonGraham S Hillis
Nov 17, 2007·Biological Psychiatry·Stéphane PotvinEdouard Kouassi
Jan 15, 2008·Biological Psychiatry·Ling Shao, Marquis P Vawter
Jan 22, 2008·The International Journal of Neuropsychopharmacology·Felicity NgAshley I Bush
Apr 22, 2008·International Journal of Epidemiology·Nikolaos A PatsopoulosJohn P A Ioannidis
Feb 4, 2010·The American Journal of Psychiatry·Alan S Brown, Elena J Derkits
Jan 25, 2011·The International Journal of Neuropsychopharmacology·Roosmarijn C DrexhageHemmo A Drexhage
Jun 7, 2011·Biological Psychiatry·Brian J MillerBrian Kirkpatrick
Sep 29, 2011·Nature Neuroscience·Marco PrinzRichard M Ransohoff
Oct 5, 2011·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Basem AzabWarren D Widmann
Mar 21, 2012·Psychiatry Research·Norbert MüllerMarkus J Schwarz
Aug 10, 2012·Journal of Leukocyte Biology·Wouter BeumerHemmo A Drexhage
Aug 28, 2012·Dementia and Geriatric Cognitive Disorders·Mehmet Emin KuyumcuServet Arıoğul
Aug 29, 2012·Molecular and Cellular Neurosciences·H B Stolp
Oct 16, 2012·Biological Psychiatry·Brian J MillerAndrew Mellor
Jan 22, 2013·Nature Neuroscience·Katrin KierdorfMarco Prinz
Feb 23, 2013·Clinical Schizophrenia & Related Psychoses·Brian J MillerMark H Rapaport
Mar 9, 2013·Angiology·Sevket BaltaMehmet Yokusoglu
Sep 21, 2013·Annual Review of Pathology·Tanya N MayadasClifford A Lowell
Oct 3, 2013·British Journal of Cancer·S BaltaT Celik
Nov 30, 2013·Biological Psychiatry·Veerle BerginkHemmo A Drexhage
Feb 22, 2014·Neuroimmunomodulation·Zuzanna Zajkowska, Valeria Mondelli
Feb 28, 2014·Journal of Vascular Surgery·Hadi J HalazunEric J Heyer
Apr 10, 2014·Nature Reviews. Neuroscience·Marco Prinz, Josef Priller
Jul 23, 2014·Molecular Psychiatry·R S Kahn, I E Sommer
Jul 25, 2014·Nature·UNKNOWN Schizophrenia Working Group of the Psychiatric Genomics Consortium
Dec 10, 2014·Schizophrenia Research·Angelica de BaumontHelena Brentani

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Citations

Jan 22, 2020·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Heather E SoderScott D Lane
Apr 28, 2020·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Andrea AgugliaGianluca Serafini
Sep 9, 2020·Psychiatry Investigation·Yasin Hasan Balcioglu, Simge Seren Kirlioglu
Dec 19, 2019·Acta Psychiatrica Scandinavica·Alricka J Jackson, Brian J Miller
Oct 31, 2020·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Qi YuYong Liu
Dec 22, 2020·Focus : Journal of Life Long Learning in Psychiatry·Brian J Miller, David R Goldsmith
Mar 30, 2021·Neuropsychiatric Disease and Treatment·Kai-Qi DingLi-Li Zeng
Jun 18, 2021·Australasian Psychiatry : Bulletin of Royal Australian and New Zealand College of Psychiatrists·Xiaoyu ZhuRan Li
Aug 11, 2021·International Journal of Psychiatry in Clinical Practice·Libor UstohalTomas Kasparek

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