Neutrophil margination and extravasation in sinusoids and venules of liver during endotoxin-induced injury

The American Journal of Physiology
J G ChosayH Jaeschke

Abstract

Neutrophils contribute to liver damage during endotoxin shock. The objective of this investigation was to document where neutrophils localize in the hepatic vasculature and whether they migrate out of sinusoids or postsinusoidal venules. A well-characterized model of galactosamine and endotoxin shock and immunostaining for neutrophil-associated migration inhibition factor-related protein complex 8/14 S100 calcium-binding proteins were used. Treatment of C3Heb/FeJ mice with 100 micrograms/kg Salmonella abortus equi endotoxin alone or in combination with 700 mg/kg galactosamine induced a time-dependent increase of neutrophil margination in sinusoids and postsinusoidal venules at 4 h. The number of venular neutrophils decreased in both groups at later time points without evidence for transmigration. Extravasation of neutrophils was only observed from sinusoids in galactosamine plus endotoxin-treated animals between 4 and 7 h, which correlated with parenchymal cell injury. After endotoxin alone, large numbers of neutrophils remained sequestered in sinusoids without injury. These data suggest that neutrophils cause hepatocellular injury during endotoxemia after extravasation and are less likely to cause damage when sequestered in th...Continue Reading

Citations

Dec 19, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Hartmut Jaeschke
Aug 16, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jeffrey R Scott, Alison E Fox-Robichaud
Mar 27, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jaspreet S GujralHartmut Jaeschke
Jan 13, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·C EipelB Vollmar
Oct 23, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·M L BajtH Jaeschke
Jan 27, 2006·World Journal of Gastroenterology : WJG·Anatol PanasiukKarol Radomski
Jul 5, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Tadashi HasegawaHartmut Jaeschke
Apr 12, 2019·Frontiers in Physiology·Hannah K DrescherHacer Sahin
Jan 13, 2004·Clinical and Diagnostic Laboratory Immunology·Daniel KlintmanHenrik Thorlacius
Oct 18, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jaspreet S GujralHartmut Jaeschke
Dec 4, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Robert B DormanHartmut Jaeschke
Dec 13, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Robert B DormanRobert W Brock
Dec 22, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Patricia F LalorDavid H Adams
May 3, 2002·Clinical and Experimental Pharmacology & Physiology·F C PenteadoJ Pedrazzoli
Apr 1, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Yoshiya ItoRobert S McCuskey
Nov 22, 2008·Journal of Pharmacological Sciences·Chien-Chuan WangMao-Hsiung Yen

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