PMID: 9186222Jun 1, 1997Paper

Neutrophil mediated microvascular injury in acute, experimental compartment syndrome

Clinical Orthopaedics and Related Research
K K SadasivanR J Korthuis

Abstract

The purpose of this study was to determine the contribution of neutrophils and tissue xanthine oxidase to the skeletal muscle microvascular dysfunction in an ex vivo model of acute compartment syndrome. Adult dogs were rendered neutropenic or depleted of tissue xanthine oxidase before gracilis muscle isolation. Compared with continuously perfused, nonischemic muscles, acute, experimental compartment syndrome resulted in a dramatic increase in microvascular permeability, muscle neutrophil content, and muscle vascular resistance. Neutropenia prevented, whereas xanthine oxidase depletion had no effect on, the microvascular dysfunction and muscle neutrophil infiltration elicited by experimental compartment syndrome. These results suggest that neutrophils contribute to the microvascular dysfunction and blood flow distribution abnormalities elicited by acute, experimental compartment syndrome.

References

Dec 1, 1976·The American Journal of Physiology·L HenquellC R Honig
Feb 9, 1989·The New England Journal of Medicine·S J Weiss
Jan 1, 1986·Acta Physiologica Scandinavica·B LarssonK E Andersson
Mar 1, 1988·The Journal of Surgical Research·P S Barie, R J Mullins
Jun 1, 1987·Journal of Applied Physiology·M B MaronK C Maender
Sep 1, 1986·Microvascular Research·C F Pilati, M B Maron
Sep 1, 1981·The Journal of Clinical Investigation·S J WeissN F Nimeh
May 1, 1994·Microvascular Research·D SeebodeH Schmid-Schönbein

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Citations

Mar 24, 2010·Clinical Orthopaedics and Related Research·Stephen R KearnsDavid Bouchier-Hayes
Mar 15, 2008·Nature Reviews. Immunology·Hajime Kono, Kenneth L Rock
Feb 12, 2011·Cell Death and Differentiation·D V KryskoP Vandenabeele
May 5, 2012·Journal of Veterinary Emergency and Critical Care·Lindsey K Nielsen, Megan Whelan
Jun 24, 2019·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Aurelia BihariAbdel-Rahman Lawendy
Apr 16, 2002·The British Journal of Surgery·A TiwariG Hamilton
Mar 27, 2002·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·D M RoachP A Cowled
Apr 13, 2011·Injury·Syed GillaniDavid J Hak

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