PMID: 8613700Apr 1, 1996Paper

Neutrophil oxidative metabolism and killing of P. brasiliensis after air pouch infection of susceptible and resistant mice

Journal of Leukocyte Biology
L H Meloni-BruneriE Burger

Abstract

The oxidative burst of polymorphonuclear neutrophils (PMN) and their ability to inhibit Paracoccidioides brasiliensis growth was studied in susceptible (B10.A) and resistant (A/J) mice. The cells were obtained after subcutaneous inoculation in air pouches, yielding highly pure PMN preparations; the number of cells was similar for both strains at 24 h and five times higher in the resistant strain at 15 days. The oxidative metabolism of these PMN was evaluated by the luminol and lucigen-enhanced chemiluminescence upon stimulation with PMA or killed P. brasiliensis (Pb). At 24 h of infection PMN from both strains showed similar responses. However, at 15 days a great enhancement of the Pb-stimulated luminol-enhanced chemiluminescence was observed only in PMN from resistant mice. Such increase was markedly inhibited by the addition of catalase. Independent of the mouse strain or time of infection of lucigen-enhanced chemiluminescence showed the same intensity. The lucigen-enhanced chemiluminescence of PMN without stimuli from resistant mice did not change with the time of infection, however, after 15 days of infection a significantly lower chemiluminescence was detected with PMN from susceptible mice. At 15 days of infection the PMN...Continue Reading

Citations

Mar 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Carlos P TabordaArturo Casadevall
Jan 24, 2007·Microbiology and Immunology·Diego Luís CostaAngela Maria Victoriano de Campos Soares
Sep 9, 2008·Mycopathologia·Vera Lúcia Garcia CalichAdriana Pina
Sep 28, 2017·Revista Da Sociedade Brasileira De Medicina Tropical·Maurício Domingues-FerreiraDewton de Moraes Vasconcelos
Apr 1, 2007·Journal of Leukocyte Biology·Vera L G Calich, Adriana Pina
Jul 1, 1997·Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology·L H Meloni-BruneriA Campa
Jan 27, 2000·Medical Mycology·A J Hamilton, M D Holdom
Apr 12, 2008·Medical Mycology·Maria Fernanda Reis Gavazzoni DiasWanderley De Souza
Mar 9, 2010·Bioscience, Biotechnology, and Biochemistry·Motoko OaradaTohru Gonoi
Apr 14, 2010·Scandinavian Journal of Immunology·M J Acorci-ValérioA M V de Campos Soares
Feb 12, 2000·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·S S KashinoV L Calich
Aug 13, 2004·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Maria Fernanda R G DiasWanderley de Souza
Mar 7, 2021·Journal of Fungi·Eva Burger
Mar 28, 1998·Microbial Pathogenesis·L KesavaluJ L Ebersole
Oct 4, 2002·Microbes and Infection·Pamela J Baker, Derry C Roopenian
May 16, 2021·Journal of Ethnopharmacology·Lauana Aparecida SantosEva Burger
Dec 19, 2007·Cytokine·Elisandra Garcia TavianAngela Maria Victoriano de Campos Soares

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.