Neutrophil phenotypes in chronic lung disease

Expert Review of Respiratory Medicine
Michael J HughesRobert Stockley

Abstract

Introduction: Neutrophils are the most abundant inflammatory cells in the lungs of patients with chronic lung diseases, especially COPD, yet despite this, patients often experience repeated chest infections. Neutrophil function may be altered in disease, but the reasons are unclear. In chronic disease, sequential pro-inflammatory and pro-repair responses appear distorted. As understanding of neutrophil heterogeneity has expanded, it is suggested that different neutrophil phenotypes may impact on health and disease. Areas covered: In this review, the definition of cellular phenotype, the implication of neutrophil surface markers and functions in chronic lung disease and the complex influences of external, local and genetic factors on these changes are discussed. Literature was accessed up to the 19 July 2019 using: PubMed, US National Library of Medicine National Institutes of Health and the National Centre for Biotechnology Information. Expert opinion: As more is learned about neutrophils, the further we step from the classical view of neutrophils being unrefined killing machines to highly complex and finely tuned cells. Future therapeutics may aim to normalize neutrophil function, but to achieve this, knowledge of phenotypes i...Continue Reading

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Citations

Feb 6, 2021·Cellular and Molecular Life Sciences : CMLS·Wan-Chi Lin, Michael B Fessler
Nov 27, 2020·Frontiers in Cell and Developmental Biology·Katia De Filippo, Sara M Rankin
Apr 22, 2021·International Journal of Chronic Obstructive Pulmonary Disease·Kay Por YipElizabeth Sapey
May 8, 2021·Expert Review of Clinical Pharmacology·Maria Gabriella MateraMario Cazzola
Aug 7, 2021·International Journal of Chronic Obstructive Pulmonary Disease·Jonathan R Baker, Louise E Donnelly
Oct 4, 2021·Environmental Science and Pollution Research International·Chen ZhaoHongwei Wang
Nov 10, 2021·The British Journal of Radiology·Avanti V Gulhane, Delphine L Chen

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