Neutrophil pool sizes and granulocyte colony-stimulating factor production in human mid-trimester fetuses

Pediatric Research
R K OhlsR D Christensen

Abstract

We quantified neutrophils and neutrophil progenitors, and assessed granulocyte colony-stimulating factor (G-CSF) production in the liver and bone marrow of 20 human abortuses after elective pregnancy termination between 14 and 24 wk of gestation. Mature neutrophils were not observed in any of the liver specimens, but were present in the bone marrow as early as 14 wk. The concentrations of neutrophils in the fetal marrow were extremely low, by comparison with term infants and adults, with less than 5% of the nucleated cells being segmented neutrophils, band neutrophils, or metamyelocytes compared with 31-69% in term infants. Despite the low neutrophil populations, progenitors which had the capacity for clonal maturation into neutrophils in vitro were abundant in the fetal liver and fetal bone marrow. In addition, such progenitors had a dose-response relationship to recombinant G-CSF similar to that of progenitors from the bone marrow of healthy adults. At each gestational age tested, stimulation of mononuclear cells from fetal liver with IL-1 alpha generated less G-CSF protein and fewer G-CSF mRNA transcripts than did stimulation of mononuclear cells from fetal bone marrow. Mononuclear cells from the fetal bone marrow produced l...Continue Reading

Citations

Mar 7, 2002·Journal of Pediatric Hematology/oncology·R K OhlsL C Sklar
Oct 2, 2007·Critical Care : the Official Journal of the Critical Care Forum·Wendy A LuceJohn Anthony Bauer
Jun 8, 2004·Pediatric Research·Tobias StrunkChristian Schultz
May 30, 2006·Seminars in Perinatology·D Wade Clapp
Jun 9, 2004·Clinics in Perinatology·Joyce M Koenig, Mervin C Yoder
Apr 1, 1996·American Journal of Obstetrics and Gynecology·D A CalhounR D Christensen
Sep 19, 2014·Frontiers in Immunology·Ismé De KleerStanislas Goriely
Jun 20, 2017·Nature Reviews. Immunology·Xiaoming ZhangRichard Lo-Man
Aug 28, 1999·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·K MatsubaraM Ito
Jun 5, 2010·International Reviews of Immunology·John Nicholas MelvanPing Zhang
Oct 11, 2019·Nature·Dorin-Mirel PopescuMuzlifah Haniffa
Sep 15, 2000·Clinics in Perinatology·D A Calhoun, R D Christensen
Sep 10, 2021·Frontiers in Immunology·Laura S PetersonBrice Gaudilliere

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