Neutrophil priming for elastase release in adult blunt trauma patients

The Journal of Trauma
Raj BhatiaIan Pallister

Abstract

Elevated plasma elastase levels have been reported following major trauma and isolated femoral fracture. Reamed femoral nailing has been shown to further increase plasma elastase levels. The aim of this study was to investigate polymorphonuclear neutrophil (PMN) priming for degranulation following major trauma and isolated long-bone/pelvis fracture by assessing the ability of PMN to release elastase in vitro in response to a stimulus. We further analyzed PMN surface expression of the integrins CD11b and CD18 as markers of PMN activation. Ten major trauma (Injury Severity Score>or=18) patients and 12 patients with isolated long-bone/pelvis fracture were included in the study. Patients in the isolated fracture group were further stratified into reamed nail and external-fixation groups following surgery. A significant increase in the capacity of PMN to release elastase was seen following major trauma, but not in isolated fracture patients. Surgery did not further alter PMN elastase release. CD11b and CD18 expression was essentially unaltered in all groups. PMN is primed for increased degranulation following major trauma but not following isolated long-bone/pelvis fracture. Accumulation of primed, hyperactive PMN into tissues can l...Continue Reading

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Citations

Aug 27, 2010·Surgery Today·Fumio KimuraMasaru Miyazaki
Oct 15, 2013·Injury·Vincenzo CirielloPeter V Giannoudis
Jan 15, 2011·Critical Care : the Official Journal of the Critical Care Forum·Adnana Paunel-GörgülüTim Lögters
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Jan 22, 2015·Journal of Veterinary Emergency and Critical Care·Nathan W PetersonJames W Barr
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Oct 21, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Adnana Paunel-GörgülüMartin Scholz
Sep 26, 2019·Frontiers in Immunology·Esmaeil MortazIan M Adcock

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