Neutrophil survival on biomaterials is determined by surface topography

Journal of Vascular Surgery
Susan ChangB Haimovich

Abstract

Cardiovascular device-centered infections are a major cause of hospital morbidity, mortality, and expense. Caused by opportunistic bacteria, this phenomenon is thought to arise because of a defect in neutrophil bacterial killing. We have shown that neutrophils that adhere to polystyrene remain viable, whereas neutrophils that adhere to the vascular biomaterials expanded polytetrafluoroethylene (ePTFE) and Dacron undergo a rapid nonapoptotic death. This study was designed to test the hypothesis that surface topography is a determinant of the nonapoptotic death response of neutrophils to biomaterials. We took advantage of the ease with which a polystyrene surface can be manipulated to examine the effect of surface topography on neutrophil viability. Neutrophils were exposed to smooth or roughened polystyrene surfaces both in vivo and in vitro. Changes in cell membrane permeability and production of reactive oxygen species by individual cells were monitored with fluorescent dyes. Host cells and isolated human neutrophils died rapidly after adhesion to roughened polystyrene. Neutrophils adherent to roughened surfaces produced more reactive oxygen intermediates than those adherent to smooth surfaces and were first to die. The cell d...Continue Reading

References

Feb 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·J D LoikeS C Silverstein
Nov 1, 1988·Journal of Vascular Surgery·W B ShueR S Greco
Apr 1, 1984·Journal of Biomedical Materials Research·T N Salthouse
Apr 1, 1984·The Journal of Clinical Investigation·W ZimmerliF A Waldvogel
Mar 1, 1983·Journal of Biomedical Materials Research·R MarchantJ M Anderson
Feb 1, 1995·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·P OlofssonR J Stoney
Jun 1, 1994·Journal of Biomedical Materials Research·S I ErtelT A Horbett
Mar 1, 1994·Journal of Biomedical Materials Research·S S KaplanR L Simmons
Jun 1, 1996·The Journal of Cell Biology·N DemaurexS Grinstein
Jun 6, 1998·The Journal of Experimental Medicine·D VercammenP Vandenabeele
Aug 3, 1999·The Journal of Clinical Investigation·M FuortesC Nathan
Oct 26, 1999·Cellular Signalling·G Berton, C A Lowell
May 24, 2000·Proceedings of the National Academy of Sciences of the United States of America·M S ShiveJ M Anderson
Apr 21, 2001·Cellular and Molecular Life Sciences : CMLS·G DeneckerP Vandenabeele
Aug 3, 2001·Nature Reviews. Molecular Cell Biology·M Leist, M Jäättelä

❮ Previous
Next ❯

Citations

Jan 27, 2016·Polski przeglad chirurgiczny·Frank MeyerJoerg Tautenhahn
Feb 5, 2008·International Journal of Laboratory Hematology·Y UemuraA Yokoyama
Jul 9, 2009·Journal of Biomedical Materials Research. Part a·Ian S MillerWilliam M Gallagher
Nov 7, 2008·Journal of Biomedical Materials Research. Part a·Kristy M AinslieTejal A Desai
May 9, 2015·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Shiuli Pujari-PalmerMarjam Karlsson Ott
Jun 2, 2004·Microscopy Research and Technique·M KarlssonM Boman
May 24, 2011·Seminars in Immunopathology·Werner Zimmerli, Parham Sendi
Oct 20, 2012·The International Journal of Artificial Organs·Carla Renata ArciolaLucio Montanaro
Sep 12, 2020·Advanced Materials·Saber Amin YavariMichiel Croes
Oct 9, 2019·Advanced Science·Chuying MaJian Yang
Dec 13, 2017·The Journal of Surgical Research·Robert D KirktonShannon L M Dahl
Apr 1, 2021·Medicine·Gisele Alborghetti NaiMariângela Esther Alencar Marques
Jul 29, 2021·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Parisa HeydariShaghayegh Haghjooy Javanmard
Apr 9, 2018·ACS Biomaterials Science & Engineering·Siddharth Jhunjhunwala
Oct 2, 2021·Frontiers in Bioengineering and Biotechnology·Gustavo A HigueraLorenzo Moroni

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Related Papers

Minimally Invasive Therapy & Allied Technologies : MITAT : Official Journal of the Society for Minimally Invasive Therapy
Marc O Schurr
IEEE Transactions on Bio-medical Engineering
Seung Jae OhSung June Kim
© 2022 Meta ULC. All rights reserved