Neutrophil-to-lymphocyte ratio, hyperglycemia, and outcomes in ischemic stroke patients treated with intravenous thrombolysis.

Brain and Behavior
Yani ChengYuanshao Lin

Abstract

Increased neutrophil-to-lymphocyte ratio (NLR) and hyperglycemia on admission are associated with poor outcomes in acute ischemic stroke (AIS) patients. We sought to evaluate the combined effect of increased NLR and hyperglycemia on the prognosis of ischemia stroke treated with intravenous thrombolysis (IVT). Patients with acute ischemic stroke receiving IVT treatment were prospectively enrolled. All participants were followed for 3 months. According to the levels of NLR and blood glucose, patients were categorized into four groups: high NLR or nonhigh NLR with or without hyperglycemia. The associations between NLR values with or without hyperglycemia and outcomes of stroke after thrombolysis were assessed by multivariable logistic regression analysis. Among the 381 stroke patients (median age 68 years, 61.68% man) included, 155 (40.68%) had a poor outcome (modified Rankin Scale score 3-6) during 3 months. After multivariate adjustment, high NLR with hyperglycemia increased the risk of 3-month poor outcome (OR = 4.42; 95% CI, 2.13-9.16), early neurological deterioration (END) (OR = 4.81; 95% CI, 2.08-11.12), and 3-month mortality (OR = 6.56; 95% CI, 1.92-22.40). A significant multiplicative interaction of NLR and blood glucose ...Continue Reading

References

Oct 6, 2001·Stroke; a Journal of Cerebral Circulation·S E CapesH C Gerstein
Feb 24, 2004·Frontiers in Bioscience : a Journal and Virtual Library·Mami IshikawaD Neil Granger
Oct 9, 2004·Stroke; a Journal of Cerebral Circulation·José Alvarez-SabínMarta Rubiera
Jan 10, 2009·Diabetes Care·Alexandre Y PoppeUNKNOWN Canadian Alteplase for Stroke Effectiveness Study Investigators
May 26, 2009·Lancet·Kathleen M DunganJean-Charles Preiser
Feb 5, 2010·Journal of Leukocyte Biology·Rong JinGuohong Li
Nov 17, 2010·Cerebrovascular Diseases·Jukka PutaalaMarkku Kaste
Jul 27, 2012·Frontiers in Immunology·Takashi ShichitaAkihiko Yoshimura
Jul 11, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·David TarrDeborah Dewar
Nov 28, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Glen C JicklingFrank R Sharp
May 31, 2014·Stroke; a Journal of Cerebral Circulation·Pierre SenersJean-Claude Baron
Aug 12, 2014·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Serhat TokgozAysegul Ogmegul
Dec 17, 2016·Translational Stroke Research·Carles JusticiaAnna M Planas
Jan 18, 2018·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J ShiC-F Liu
Apr 9, 2018·Journal of the Neurological Sciences·Sheng-Feng LinUNKNOWN Taiwan Thrombolytic Therapy for Acute Ischemic Stroke (TTT-AIS) Study Group
Jun 29, 2018·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·K MalhotraG Tsivgoulis
Aug 30, 2019·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Huihui LiuYongjun Cao

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