Neutrophil to Lymphocyte Ratio (NLR) at the Time of Transurethral Resection of Bladder Tumor: A Large Retrospective Study and Analysis of Racial Differences

Bladder Cancer
Ngii N TazehTracy M Downs

Abstract

Introduction: Neutrophil/lymphocyte ratio (NLR) is an indicator of systemic inflammation and has been proven to be associated with an increased risk of extravesical disease, decreased cancer specific survival and overall survival in bladder cancer patients. A large proportion of healthy African Americans have a WBC count that is persistently lower than the normal range defined for individuals of European ancestry, this condition has been called "benign ethnic neutropenia". The purpose of our study was to determine if NLR was different in patients of African ancestry (AA) vs European ancestry (EA) across different tumor grades and stages at the time of transurethral resection of bladder tumor(s) (TURBT). Materials and Methods: The records of consecutive patients who underwent TURBT were reviewed from the University of Wisconsin and the Atlanta Veterans' Administration Medical Center (2000-2012). NLR was compared across tumor stage, tumor grade and ethnicity. Results: 297 consecutive patients met study criteria. 89% and 86%, were males and of European ancestry (EA) respectively. NLRs were different across T-stages (Ta-2.5, T1-3.9, T2-3.8; p = 0.001). but not across tumor grades in Ta (LG-2.5 vs HG-3.9, p = 0.57). EA had higher NL...Continue Reading

References

Aug 5, 1976·The New England Journal of Medicine·L H MillerM H McGinniss
Mar 7, 2001·Lancet·F Balkwill, A Mantovani
Dec 10, 2002·International Journal of Cancer. Journal International Du Cancer·Helmut SchaiderMeenhard Herlyn
Dec 20, 2002·Nature·Lisa M Coussens, Zena Werb
Aug 25, 2005·Journal of Surgical Oncology·S R WalshN J Keeling
Mar 10, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Léon C L van KempenLisa M Coussens
Apr 8, 2006·The American Journal of Clinical Nutrition·John E MorleyMargaret-Mary G Wilson
Jun 10, 2006·The American Journal of Clinical Nutrition·Kenneth C FearonUNKNOWN Cancer Cachexia Study Group
Feb 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lukas A HeflerAlexander Reinthaller
Jul 25, 2008·Nature·Alberto MantovaniFrances Balkwill
Mar 23, 2010·Cell·Sergei I GrivennikovMichael Karin
Sep 8, 2010·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Hideaki ShimadaMatsuo Nagata
Aug 25, 2011·British Journal of Cancer·J Pascoe
Aug 3, 2012·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·S CedrésE Felip
Mar 20, 2014·PloS One·Yong WeiWen-Hui Qian

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Disparities

Cancer disparities refers to differences in cancer outcomes (e.g., number of cancer cases, related health complications) across population groups.

Related Papers

Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
Eyup BuyukkayaNihat Sen
Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
S CedrésE Felip
© 2022 Meta ULC. All rights reserved