Neutrophil-to-lymphocyte ratio predicts diagnosis and prognosis of idiopathic sudden sensorineural hearing loss: A systematic review and meta-analysis

Medicine
Liquan ChenJiayuan Wu

Abstract

Chronic inflammation has been regarded as one of the causes of idiopathic sudden sensorineural hearing loss (ISSHL). Several individual studies have reported the association between neutrophil-to-lymphocyte ratio (NLR) and ISSHL. However, the findings have been inconsistent, and these data have not been systematically evaluated. Thus, we conducted this meta-analysis to further explore the predictive value of NLR on formation and prognosis of ISSHL. A comprehensive literature search was performed to identify eligible studies based on PubMed, Embase, Web of Science, and China National Knowledge Infrastructure. The Standardized mean deviation (SMD) with its 95% confidence interval (CI) was applied to be the effect size estimate. A total 10 papers with 15 retrospective case-control studies, which included 1029 ISSHL patients (the case group) and 1020 healthy people (the control group), were selected for the meta-analysis of the relationship between NLR and onset of ISSHL. The NLR levels in the case group were observed to be higher than the control group (SMD = 1.65, 95% CI = 1.20-2.09, P < .001). The pooled results did not significantly change by the subgroup analyses based on study region, baseline matching, and laterality. Moreov...Continue Reading

References

Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Sep 27, 2005·Lancet·George A Gates, John H Mills
Dec 5, 2006·Brazilian Journal of Otorhinolaryngology·Paulo Roberto Lazarini, Ana Cristina Kfouri Camargo
Nov 14, 2008·Audiology & Neuro-otology·F BallesterosM Bernal-Sprekelsen
Jan 22, 2010·The Laryngoscope·Jason K M Chau, Richard L Goode
Apr 7, 2010·Lancet·Benjamin E SchreiberLinda M Luxon
May 25, 2011·Trends in Amplification·Maggie KuhnPamela C Roehm
Mar 14, 2012·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Robert J StachlerUNKNOWN American Academy of Otolaryngology-Head and Neck Surgery
Aug 9, 2012·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Masatsugu MasudaKaoru Ogawa
May 18, 2013·JAMA Otolaryngology-- Head & Neck Surgery·Stefano BerrettiniRaffaello Canapicchi
Jun 7, 2013·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Scott D NashTheodore S Tweed
Aug 31, 2013·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Sahin UluAbdullah Aycicek
Oct 15, 2013·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Sahin UluAbdullah Aycicek
May 3, 2014·The Journal of Craniofacial Surgery·Gül Soylu Özler
Aug 1, 2012·Seminars in Hearing·Dennis R Trune, Anh Nguyen-Huynh
Oct 30, 2014·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Elisabeth Hultcrantz, Ramesh Nosrati-Zarenoe
Jan 3, 2015·Atherosclerosis·Mary E FischerKaren J Cruickshanks
Feb 7, 2015·Diabetes & Metabolism·M VerdoiaUNKNOWN Novara Atherosclerosis Study Group (NAS)
Apr 14, 2015·Expert Review of Neurotherapeutics·Tomasz Dziedzic
Jun 19, 2015·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Hang LiShuyi Pan
Oct 21, 2015·Brazilian Journal of Otorhinolaryngology·Rauf Oğuzhan KumYonca Avci
Dec 26, 2015·The Journal of Craniofacial Surgery·Kasim DurmuşEmine Elif Altuntaş
Mar 10, 2016·Advanced Biomedical Research·Nezamoddin BerjisSafoura Nasiri
Sep 3, 2016·Audiology Research·Nicola QuarantaAlessandra D'Elia
May 10, 2017·European Annals of Otorhinolaryngology, Head and Neck Diseases·H E KoçakF T Kayhan
Apr 24, 2018·Clinica Chimica Acta; International Journal of Clinical Chemistry·Zaizai CaoBobei Chen

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Oct 4, 2020·International Journal of Molecular Sciences·Jeon Gang DooSeung Geun Yeo
Nov 19, 2020·International Journal of Molecular Sciences·Dorota Olex-Zarychta
Sep 10, 2019·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·Sagit ShushanYahav Oron

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