Neutrophil to lymphocyte ratio predicts SYNTAX score in patients with non-ST segment elevation myocardial infarction

International Heart Journal
Serkan KurtulMehmet G Kaya

Abstract

In this study we aimed to investigate whether there is an association between the neutrophil to lymphocyte ratio (NLR) and severity of coronary artery disease (CAD) in patients with non-ST segment elevation myocardial infarction (NSTEMI) using the SYNTAX score (SXscore). A total of 414 patients with NSTEMI who underwent coronary angiography were enrolled in the study. NLR was measured for all patients at presentation. The study population was then divided into 3 tertiles based on the SYNTAX trial results.(1)) The low syntax group (n = 329) was defined as those with an SXscore ≤ 22, the intermediate syntax group (n = 58) was defined as an SXscore ≥ 23 and < 33, and the high syntax group (n = 27) as those with an SXscore ≥ 33. NLR was significantly lower in patients with a low SXscore compared to patients with an intermediate SXscore or high SXscore (3.7 ± 4 to 4.6 ± 2 and 7.9 ± 4, P < 0.001). Linear regression analysis revealed that NLR (coefficientβ = 0.380, 95%CI: 1.165-1.917, P < 0.001) was significantly associated with the SXscore in patients with NSTEMI. Our results indicate that NLR is independently associated with the severity of CAD in patients with NSTEMI.

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Citations

Feb 16, 2016·Expert Review of Cardiovascular Therapy·Maxwell E Afari, Tariq Bhat
Jan 14, 2018·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Na XuJin-Qing Yuan
Apr 19, 2018·PloS One·José Gildo de Moura Monteiro JúniorDário Celestino Sobral Filho
Nov 12, 2016·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Handan Inonu KoseogluOsman Demir
Jan 13, 2016·Journal of Atherosclerosis and Thrombosis·Shuaibo HuangChun Liang
Mar 28, 2020·Mediators of Inflammation·Yueqiang WenXianfeng Wu
Jul 25, 2021·Journal of Clinical Medicine·Tomasz Kamil UrbanowiczMarek Jemielity

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