Neutrophil volume distribution width: a new automated hematologic parameter for acute infection.

Archives of Pathology & Laboratory Medicine
Fernando ChavesDongsheng Xu

Abstract

The number of band forms and immature neutrophils increases during acute bacterial infection. However, the determination of band counts and other neutrophil morphologic changes, such as the presence of toxic granulation, toxic vacuolization, and Dohle bodies in the cytoplasm, is labor intensive and time consuming, as it requires manual examination by an experienced medical technologist. To investigate the value of the neutrophil volume distribution width (NDW), generated by VCS technology of the Coulter LH 750 hematology analyzer, as an additional predictor of acute infection. Total white blood cell count, percentage of neutrophils, and NDW data from 70 patients with positive blood cultures for bacteria and from 35 age-matched control subjects were retrospectively analyzed. A significant increase in the NDW was observed in the bacteremic patients compared with the controls (24.7 +/- 4.5 vs 19.0 +/- 1.5; P < .001). Such increase was observed even in patients with white blood cell counts less than 11,000/microL (23.0 +/- 5.6 vs 19.0 +/- 1.5; P < .001) or with percentages of neutrophils less than 85% (24.0 +/- 4.9 vs 19.0 +/- 1.5; P < .001). The more dramatic increases were seen in patients with leukocytosis (25.7 +/- 3.2, P < .00...Continue Reading

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Citations

Nov 14, 2015·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·N ZhouX Song
Nov 9, 2006·Archives of Pathology & Laboratory Medicine·Gregory Tetrault
Mar 7, 2019·Clinical Chemistry and Laboratory Medicine : CCLM·Eloísa UrrechagaUrko Aguirre
Sep 28, 2020·International Journal of Laboratory Hematology·Xiaoqian ZengDongsheng Xu
Nov 16, 2020·International Journal of Laboratory Hematology·Flávio Augusto NaoumMaria Gabriela de Lucca Oliveira
Mar 14, 2007·Laboratory Hematology : Official Publication of the International Society for Laboratory Hematology·Robert BagdasaryanDongsheng Xu
Nov 21, 2007·Clinical Chemistry and Laboratory Medicine : CCLM·Elisabeth Haschke-BecherChristian Gabriel
Apr 29, 2009·Clinical Chemistry and Laboratory Medicine : CCLM·Karin J VelthoveMadelon Bracke
Nov 26, 2009·International Journal of Laboratory Hematology·S Koenig, K Quillen
Sep 23, 2011·Laboratory Hematology : Official Publication of the International Society for Laboratory Hematology·Y ZhuD Xu
Feb 23, 2011·International Journal of Laboratory Hematology·D-H ParkK Han
Nov 1, 2011·Clinical Biochemistry·Francesco RaimondiLetizia Capasso Ed Ernesto Grimaldi
Jun 24, 2011·Scandinavian Journal of Infectious Diseases·Khalil M CharafeddineRose T Daher

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