Neutrophilic defensins penetrate the blood-brain barrier

Journal of Neuroscience Research
H Schluesener, R Meyermann

Abstract

Defensins are small, cationic, cyclic peptides that are abundantly stored in granules of neutrophils. Defensins non-specifically interact with membranes by forming weakly ion-selective pores. Here we demonstrate immunolocalization of defensin-secreting cells in human brain. Defensins, secreted by activated granulocytes, apparently are not prevented by the blood-brain barrier (BBB) from diffusing across cerebral endothelium to penetrate the neuropil for a considerable distance from the granulocyte. This is in contrast to other neutrophil proteins like the granule-associated enzyme elastase or the cytosolic protein MRP-14, which are strictly localized to the cytoplasm or granules of neutrophils. Thus, defensins, known chemokinetic and chemotactic molecules, display a unique distribution at BBB sites.

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Citations

Jul 30, 2010·Archivum Immunologiae Et Therapiae Experimentalis·Yanhua SuHermann J Schluesener
Nov 14, 2001·Infection and Immunity·M E KlutJ C Hogg
Aug 2, 2000·Proceedings of the National Academy of Sciences of the United States of America·R E Hancock, M G Scott
Dec 29, 2004·Journal of Drug Targeting·Paul R LockmanDavid D Allen
Jul 6, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Shamim MushtaqJawed Shafqat
Jan 30, 2014·Medical Hypotheses·Jannis KountourasOlga Giouleme
Feb 9, 2018·Journal of Translational Medicine·Driton Vela
May 20, 2018·Journal of Neuroinflammation·Yang-Wuyue LiuShuang-Shuang Dai
Oct 31, 2018·Frontiers in Neuroscience·Driton Vela
Nov 13, 2019·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Shelly AonoEdward E Morrison

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