Neutrophilic dermatosis (pustular vasculitis) of the dorsal hands: a report of 7 cases and review of the literature

Archives of Dermatology
David J DiCaudo, Suzanne M Connolly

Abstract

Neutrophilic dermatosis (pustular vasculitis) of the dorsal hands is a recently described disorder, which may clinically resemble a localized variant of Sweet syndrome. To describe the clinical and histopathologic characteristics of this rare disorder; to compare and contrast these features with those of Sweet syndrome; and to investigate possible associations with systemic diseases. Seven women were referred for pustular or ulcerative plaques and nodules on the dorsal hands. In most patients, the initial diagnosis was cutaneous infection, but antibiotic therapy was ineffective. Skin biopsy specimens showed dense dermal neutrophilic infiltrates with leukocytoclasis and fibrinoid vascular necrosis. Cutaneous cultures yielded negative findings in all cases. Prednisone and dapsone appeared to be helpful, but recurrences were common. Minocycline hydrochloride was of uncertain benefit. Among the 7 patients, possible systemic associations included bowel disorders and a urinary tract infection. Neutrophilic dermatosis of the dorsal hands may be closely related to Sweet syndrome but frequently shows the histologic pattern of leukocytoclastic vasculitis. Recognition of this disorder is important, because it may be misdiagnosed as a loca...Continue Reading

Citations

Feb 16, 2005·Rheumatology International·M J F Starmans-KoolH H M L Houben
Apr 7, 2007·The American Journal of Dermatopathology·Gudrun RatzingerBernhard Zelger
Dec 4, 2003·Contact Dermatitis·L Stransky, V Broshtilova
Aug 20, 2009·Pediatric Dermatology·James Halpern, Asad Salim
Jul 28, 2007·Orphanet Journal of Rare Diseases·Philip R Cohen
Aug 8, 2009·American Journal of Clinical Dermatology·Kelley V EubankMadeleine Duvic
Sep 17, 2005·Journal of the European Academy of Dermatology and Venereology : JEADV·H K LarsenK Weismann
Oct 16, 2004·Journal of the European Academy of Dermatology and Venereology : JEADV·F AydinAy Turanli
Jul 6, 2004·The Journal of Dermatology·Donna BiluCarlos H Nousari
Oct 13, 2006·The British Journal of Dermatology·M R KaurK S Ryatt
Feb 16, 2007·The British Journal of Dermatology·C Y NeohS K Ng
Mar 14, 2007·The Journal of Dermatology·Jesús Del PozoEduardo Fonseca
Jul 16, 2008·Journal of the European Academy of Dermatology and Venereology : JEADV·Y-S Wang, A Tan
Dec 15, 2005·Advances in Dermatology·Karla S DraftRosalie Elenitsas
Jan 24, 2006·International Journal of Dermatology·Rodrigo Pereira DuquiaJoel Schwartz
Mar 13, 2014·La Revue de médecine interne·L BoussofaraR Nouira
Jun 12, 2004·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·O A PaoluziP Paoluzi
Oct 2, 2012·Dermatologic Clinics·Maxwell A Fung, Keira L Barr
Nov 23, 2012·The Journal of Hand Surgery, European Volume·C W JoyceP Meagher
Oct 3, 2003·International Journal of Dermatology·Philip R Cohen, Razelle Kurzrock
May 6, 2004·International Journal of Dermatology·Roger H WeenigMark D P Davis
Apr 30, 2017·The American Journal of Dermatopathology·Ana Ortins-PinaLuís Soares-de-Almeida
Apr 3, 2008·American Journal of Hematology·Robert H Cook-NorrisLawrence E Gibson
Jan 9, 2010·Histopathology·J Andrew Carlson
Jan 21, 2003·Archives of Dermatology·William D James
Jan 21, 2003·Archives of Dermatology·Nakhle Ayoub, Roland Tomb
Dec 22, 2010·Acta Medica (Hradec Králové)·Francisco José Fernández-FernándezPascual Sesma
Apr 21, 2004·Seminars in Cutaneous Medicine and Surgery·Anne Wilkerson, Bruce Smoller
Aug 30, 2018·Anais Brasileiros De Dermatologia·Felipe Siqueira RamosMarcia Lanzoni de Alvarenga Lira
Jan 1, 2018·Anais Brasileiros De Dermatologia·Felipe Siqueira RamosMarcia Lanzoni de Alvarenga Lira
Apr 3, 2021·Journal of Emergency Nursing : JEN : Official Publication of the Emergency Department Nurses Association·Derrick PhillipsKok Ngan
Jul 17, 2021·Anais Brasileiros De Dermatologia·Marcial Álvarez-SalafrancaBegoña de Escalante Yangüela

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.