Neutrophilic Epitheliotropism is a Histopathological Clue to Neutrophilic Urticarial Dermatosis

The American Journal of Dermatopathology
Sigrid M C BroekaertDieter Metze

Abstract

Neutrophilic urticarial dermatosis (NUD) comprises a particular autoinflammatory condition within the spectrum of aseptic neutrophilic dermatoses characterized by a distinct urticarial eruption clinically and a neutrophilic dermatosis histopathologically. In this study, we reviewed skin biopsies of lesional skin of patients seen in our outpatient clinic for autoimmune dermatoses and in allergy department from 1982 to 2014 that fulfilled these criteria. A total of 77 biopsies from 50 patients were analyzed histopathologically. Included were cases of Schnitzler syndrome, Still disease, systemic lupus erythematosus, Sjögren syndrome, cryopyrin-associated periodic syndrome, primary biliary cirrhosis, inflammatory bowel disease, and those that had signs of systemic inflammation not otherwise specified, that is, fever, arthritis, leukocytosis, and elevated erythrocyte sedimentation rate. A control cohort was defined as including a total of 70 biopsies from 50 patients comprising neutrophilic urticaria (pressure-induced and not pressure-induced), conventional urticaria, lupus erythematosus expressing neutrophils, and exanthematous drug reaction of macular type expressing neutrophils. Skin biopsies of NUD revealed a perivascular and in...Continue Reading

References

Jul 1, 1985·The British Journal of Dermatology·M S Peters, R K Winkelmann
Jul 20, 2005·Archives of Dermatology·Luis RequenaEvaristo Sánchez Yus
Sep 1, 2006·PLoS Medicine·Dennis McGonagle, Michael F McDermott
Jun 30, 2007·Nature Clinical Practice. Rheumatology·Dirk FoellJohannes Roth
May 4, 2011·Current Rheumatology Reports·Raphaela Goldbach-Mansky
Jul 26, 2011·The American Journal of Dermatopathology·Majdy NaimDieter Metze
Jan 17, 2013·Expert Opinion on Therapeutic Targets·Akiko YamadaNaozumi Ishimaru
Mar 23, 2013·The American Journal of Dermatopathology·Marcela Saeb-LimaJudith Domínguez-Cherit
May 30, 2013·JAMA Dermatology·Hrishikesh BelaniKieron S Leslie
Oct 15, 2013·The British Journal of Dermatology·E ChristophersM Röcken

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Citations

Nov 20, 2016·Journal of Cutaneous Pathology·Cuong V Nguyen, Daniel D Miller
Dec 23, 2017·Clinical and Experimental Dermatology·A SalamD H McGibbon
Nov 13, 2018·Advances in Anatomic Pathology·Lauren PennClaudia I Vidal
Jun 6, 2019·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·F F Gellrich, C Günther
Sep 29, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·L Gusdorf, D Lipsker
Apr 8, 2020·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·J Ehrchen, C Drerup
Sep 10, 2020·Clinical and Experimental Dermatology·J Oldham, H J Lachmann
Jul 19, 2017·Current Rheumatology Reports·L Gusdorf, D Lipsker
Sep 1, 2018·Pediatric Dermatology·Irene LatourAntonio Torrelo
Jun 6, 2018·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·A Böer-Auer, R Fölster-Holst
Sep 1, 2018·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·F F Gellrich, C Günther
Jan 23, 2019·Zeitschrift für Rheumatologie·F F Gellrich, C Günther
Apr 28, 2016·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·J Ehrchen
Apr 19, 2020·Der Pathologe·Sigrid M C Möckel, Dieter Metze
Nov 19, 2019·Frontiers in Immunology·Ignasi Figueras-NartJosé Hernández-Rodríguez
Sep 5, 2019·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Erik PetersonK Lo Sicco
Oct 20, 2020·Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Società Italiana Di Dermatologia E Sifilografia·Irene Latour-Álvarez, Antonio Torrelo
Dec 10, 2020·Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Società Italiana Di Dermatologia E Sifilografia·Laurence Gusdorf, Dan Lipsker
Jul 18, 2021·Clinics in Dermatology·Laurence FeldmeyerLuca Borradori
Jan 22, 2020·Arthritis Care & Research·Fawad AslamDavid J DiCaudo
Oct 6, 2021·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·T P VoigtA Tsianakas

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