Neutrophils ameliorate lung injury and the development of severe disease during influenza infection

The Journal of Immunology : Official Journal of the American Association of Immunologists
Michelle D TatePatrick C Reading

Abstract

The clinical response to influenza infection ranges from mild disease to severe pneumonia and it remains unclear whether the inflammatory response to infection is protective or pathogenic. We have defined a novel role for neutrophils in ameliorating lung injury during influenza infection, thereby limiting development of severe disease. Infection of neutrophil-depleted mice with influenza virus HKx31 (H3N2) led to rapid weight loss, pneumonia, and death. Neutropenia was associated with enhanced virus replication in the respiratory tract; however, viral titers were declining at the time of death, leading us to investigate other factors contributing to mortality. In addition to thymic atrophy, lymphopenia, and viremic spread, depletion of neutrophils led to exacerbated pulmonary inflammation, edema, and respiratory dysfunction. Thus, while it is well established that neutrophils contribute to lung injury in a range of pathological conditions, reduced numbers or impaired neutrophil function can facilitate progression of mild influenza to severe clinical disease.

References

Jul 1, 1991·The Journal of General Virology·M C EichelbergerP C Doherty
Dec 1, 1986·Journal of Virology·K A DaherR I Lehrer
Aug 28, 1986·The New England Journal of Medicine·F P OgnibeneJ E Parrillo
Sep 1, 1986·Journal of Applied Physiology·M J LaughlinS Matalon
Mar 1, 1985·Journal of Applied Physiology·J U RajR D Bland
Jan 1, 1981·Microbiology and Immunology·M SakamotoN Ishida
Nov 1, 1981·The Journal of Clinical Investigation·W J MartinR G Crystal
Mar 1, 1994·The Journal of General Virology·E M AndersR A Ezekowitz
Dec 1, 1995·American Journal of Respiratory and Critical Care Medicine·T TerashimaA Ishizaka
Jan 1, 1996·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·G R BurlesonL S Birnbaum
Mar 8, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·D VremecK Shortman
Dec 29, 2000·The Tohoku Journal of Experimental Medicine·T OhruiH Sasaki
Mar 20, 2001·American Journal of Respiratory and Critical Care Medicine·Y KitamuraH Nakajima
May 5, 2001·Journal of Virological Methods·A M LeVineJ M Stark
Sep 18, 2001·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·A J SchlueterX Li
Nov 21, 2002·The European Journal of Surgery = Acta Chirurgica·Andrew J Aldridge
Feb 4, 2003·Current Allergy and Asthma Reports·Madeleine Ennis
Apr 12, 2003·Critical Care Medicine·Edward Abraham
Jun 20, 2003·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Susan J Baigent, John W McCauley
Aug 9, 2003·Chest·Djamel MokartJean-Louis Mege
Mar 12, 1959·The New England Journal of Medicine·R OSEASOHNM KAJI
Aug 6, 2004·The Pediatric Infectious Disease Journal·Charles Grose, Kulkanya Chokephaibulkit
Oct 8, 2005·Science·Terrence M TumpeyAdolfo García-Sastre
Nov 30, 2005·Cellular and Molecular Life Sciences : CMLS·M J HeroldH M Reichardt
May 10, 2006·The Journal of Experimental Medicine·Joost J SmitNicholas W Lukacs
May 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kevan L HartshornErika C Crouch
Aug 19, 2006·American Journal of Respiratory and Critical Care Medicine·Tong XuChanggui Dong
Jan 24, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Steven R BeatySun-Sang J Sung

❮ Previous
Next ❯

Citations

Apr 13, 2011·Immunology and Cell Biology·Michelle D TateJustine D Mintern
Jan 24, 2012·Nature Reviews. Immunology·Susan L SwainTara M Strutt
Mar 10, 2012·Nature Reviews. Immunology·Thomas J BracialeTaeg S Kim
Oct 7, 2010·Proceedings of the National Academy of Sciences of the United States of America·Daniel KreiselMark J Miller
Mar 27, 2013·Proceedings of the National Academy of Sciences of the United States of America·Vernon T PhanNapoleone Ferrara
Nov 19, 2013·DNA and Cell Biology·Christelle GabrielLisa F P Ng
Aug 18, 2010·Viral Immunology·Josep Bassaganya-RieraRaquel Hontecillas
Jul 28, 2011·The Journal of Infectious Diseases·Dapeng GongEileen Remold-O'Donnell
Oct 24, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Vanessa De VooghtJeroen A J Vanoirbeek
May 13, 2011·American Journal of Respiratory Cell and Molecular Biology·Sanjukta GhoshLester Kobzik
Jun 9, 2012·American Journal of Respiratory Cell and Molecular Biology·Famke AeffnerIan C Davis
Jul 24, 2012·The Journal of Clinical Investigation·K Kai McKinstrySusan L Swain
Mar 23, 2011·PloS One·Michelle D TatePatrick C Reading
Jan 25, 2013·Viruses·Elske van den BergReinout A Bem
Nov 7, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jennifer L H WheelerB Paige Lawrence
Jan 29, 2014·Immunology and Cell Biology·Amali E SamarasingheJonathan A McCullers
May 28, 2013·Archivum Immunologiae Et Therapiae Experimentalis·K Kai McKinstryTara M Strutt
Mar 15, 2014·PLoS Pathogens·Nathan L BowersZdenek Hel
Mar 13, 2014·Acta Neuropathologica Communications·Veit RothhammerThomas Korn
Aug 14, 2015·Journal of Analytical Science and Technology·Youri LeeSang-Moo Kang
Mar 10, 2015·American Journal of Respiratory and Critical Care Medicine·Alan Chen-Yu HsuPhilip M Hansbro
Nov 26, 2011·Blood·Alexander M de BruinMartijn A Nolte

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.