Neutrophils and arthritis: Role in disease and pharmacological perspectives

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Victor FattoriWaldiceu A Verri

Abstract

The inflammatory response in the joint can induce an intense accumulation of leukocytes in the tissue that frequently results in severe local damage and loss of function. Neutrophils are essential cells to combat many pathogens, but their arsenal can contribute or aggravate articular inflammation. Here we summarized some aspects of neutrophil biology, their role in inflammation and indicated how the modulation of neutrophil functions could be useful for the treatment of different forms of arthritis.

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Citations

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Mar 20, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Carla F S GuazelliWaldiceu A Verri

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