Neutrophils and macrophages cooperate in host resistance against Leishmania braziliensis infection

The Journal of Immunology : Official Journal of the American Association of Immunologists
Fernanda O NovaisCamila I de Oliveira

Abstract

Neutrophils play an active role in the control of infections caused by intracellular pathogens such as Leishmania. In the present study, we investigated the effect of neutrophil depletion at the time of Leishmania braziliensis infection of BALB/c mice and how neutrophils interact with the infected macrophage to promote parasite elimination. The in vivo depletion of neutrophils led to a significant increase in parasite load and enhanced the Th1-Th2 immune response in this experimental model of infection. BALB/c mice coinoculated with both parasites and live neutrophils displayed lower parasite burdens at the site of infection and in the draining lymph nodes. In vitro, we observed that live neutrophils significantly reduced the parasite load in L. braziliensis-infected murine macrophages, an effect not observed with Leishmania major. L. braziliensis elimination was dependent on the interaction between neutrophils and macrophages and was associated with TNF-alpha as well as superoxide production. Furthermore, cooperation between neutrophils and macrophages toward parasite elimination was also observed in experiments performed with L. braziliensis-infected human cells and, importantly, with two other New World Leishmania species. T...Continue Reading

References

Mar 30, 1984·Science·D L Sacks, P V Perkins
Aug 29, 1995·Proceedings of the National Academy of Sciences of the United States of America·V GoossensW Fiers
Jan 1, 1995·Immunology Today·M A Cassatella
Dec 31, 1998·Immunology Letters·G M LimaI A Abrahamsohn
Mar 22, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·S C SmeltP M Kaye
Aug 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·F Tacchini-CottierJ A Louis
Feb 17, 2001·Nitric Oxide : Biology and Chemistry·K M MirandaD A Wink
Feb 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·K TatedaT J Standiford
May 22, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·V A FadokP M Henson
Jul 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·K R GanttM E Wilson
Oct 10, 2001·Current Biology : CB·P M HensonV A Fadok
May 15, 2002·FEMS Microbiology Letters·Kathleen A RogersRichard G Titus
Jul 5, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·K VenuprasadBhaskar Saha
Dec 4, 2002·Nature Reviews. Immunology·John SavillChris Haslett
Jun 10, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chang-Hoon WooJae-Hong Kim
Nov 14, 2003·Microbes and Infection·Mikkel Faurschou, Niels Borregaard
Mar 23, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Flávia L Ribeiro-GomesGeorge A DosReis
Sep 21, 2004·Parasitology Research·Tatiani Uceli MaioliLuís Carlos Crocco Afonso
Feb 25, 2006·Nature Reviews. Immunology·Carl Nathan
May 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cindy AllenbachFabienne Tacchini-Cottier
Jul 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Belinda H TanSteffen Stenger
Dec 13, 2006·Trends in Microbiology·Rui Appelberg
Feb 14, 2007·Microbes and Infection·Anderson Sá-NunesLúcia H Faccioli
Apr 24, 2007·Journal of Leukocyte Biology·Mélanie CharmoyFabienne Tacchini-Cottier
Jul 25, 2007·International Journal for Parasitology·Deborah F SmithAngela K Cruz
Sep 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Flavia L Ribeiro-GomesGeorge A DosReis
Sep 14, 2007·Immunological Reviews·William M Nauseef
Feb 10, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ricardo KhouriJohan Van Weyenbergh
Apr 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Anderson B Guimarães-CostaElvira M Saraiva

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Citations

Sep 14, 2010·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Douglas D BensonCarlton C Barnett
Jun 27, 2013·Infection and Immunity·Sandra Bonne-AnnéeDavid Abraham
Jun 19, 2010·PLoS Neglected Tropical Diseases·Tatiana R de MouraCamila I de Oliveira
Oct 3, 2013·PLoS Neglected Tropical Diseases·Irazú ContrerasMartin Olivier
Nov 18, 2010·PloS One·Erico Vinícius de Souza CarmoClara Lúcia Barbiéri
Jan 10, 2014·The Journal of Infectious Diseases·Fernanda O NovaisPhillip Scott
Aug 29, 2014·Molecular Biology of the Cell·Johnathan CantonSergio Grinstein
Mar 24, 2016·Nature Immunology·Amariliz RiveraWilliam C Gause
Apr 2, 2016·Cellular and Molecular Life Sciences : CMLS·Prajwal Gurung, Thirumala-Devi Kanneganti
Apr 17, 2012·Journal of Parasitology Research·Deboraci Brito PratesValéria Matos Borges
May 10, 2012·Journal of Parasitology Research·Maria Fátima HortaLeda Quercia Vieira
Jul 19, 2016·Nature Reviews. Immunology·Phillip Scott, Fernanda O Novais
Sep 24, 2016·Pathogens and Global Health·Nahid MaspiFathemeh Ghaffarifar
Jun 21, 2012·Anais Brasileiros De Dermatologia·Linton Wallis Figueiredo SouzaAna Cristina Carvalho Botelho
Jan 4, 2017·PLoS Neglected Tropical Diseases·Ciaran J McCoyAdrian J Wolstenholme
Dec 9, 2017·Frontiers in Immunology·Graziele Quintela-CarvalhoValeria M Borges
Dec 19, 2017·Frontiers in Immunology·Ivo B RegliFabienne Tacchini-Cottier
Sep 21, 2017·Parasite Immunology·B F M AlmeidaV M F Lima
Jan 10, 2018·Frontiers in Immunology·Niloofar Karaji, Quentin J Sattentau
May 12, 2016·PLoS Neglected Tropical Diseases·Jacilara ConceiçãoOlívia Bacellar
Mar 11, 2015·PLoS Neglected Tropical Diseases·Sarah A C FalcãoCamila I de Oliveira
Jul 13, 2011·Nature Reviews. Microbiology·Paul Kaye, Phillip Scott
Mar 4, 2011·Cellular and Molecular Life Sciences : CMLS·Alessandra A FilardyGeorge A DosReis
Jul 2, 2019·PLoS Neglected Tropical Diseases·Matthew S YorekPrajwal Gurung
Mar 25, 2015·Seminars in Immunopathology·Fernanda O Novais, Phillip Scott
May 21, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lijun XinLynn Soong
Jan 14, 2011·Parasite Immunology·R NovoaE M Carvalho
Feb 26, 2011·Immunological Reviews·Evelyne MougneauNicolas Glaichenhaus
Jul 2, 2015·Clinical and Experimental Immunology·E D CarlsenL Soong
Sep 7, 2016·Parasites & Vectors·Mariana M ChavesRobson Coutinho-Silva
Mar 5, 2015·PLoS Neglected Tropical Diseases·Lu HuangSusana Mendez
Nov 2, 2017·Memórias do Instituto Oswaldo Cruz·Taís M CamposLucas P Carvalho
Jul 13, 2019·Frontiers in Cellular and Infection Microbiology·Laíse B OliveiraCamila I de Oliveira

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