Neutrophils are important in early control of lung infection by Yersinia pestis

Microbes and Infection
Thomas R LawsRoman A Lukaszewski

Abstract

In this paper we evaluate the role of neutrophils in pneumonic plague. Splenic neutrophils from naïve BALB/c mice were found to reduce numbers of culturable Yersinia pestis strain GB in suspension. A murine, BALB/c, intranasal model of pneumonic plague was used in conjunction with in vivo neutrophil ablation, using the GR-1 antibody. This treatment reduced neutrophil numbers without affecting other leukocyte numbers. Neutrophil ablated mice exhibited increased bacterial colonisation of the lung 24h post infection. Furthermore, exposure of Y. pestis to human neutrophils resulted in a 5-fold reduction in the number of viable bacterial cells, whereas, PBMCs had no effect.

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Citations

Jan 5, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Young Hee NamMyeong Heon Shin
Aug 24, 2011·Infection and Immunity·Nathaniel D LambertDavid S Bradley
Oct 8, 2013·PLoS Pathogens·Roger D PechousWilliam E Goldman
Oct 22, 2014·Journal of Immunology Research·Julia A TreeCaroline A Rowland
Feb 7, 2016·Comparative Immunology, Microbiology and Infectious Diseases·Jin-A ChoiJong-Hwan Park
Dec 1, 2012·Comparative Immunology, Microbiology and Infectious Diseases·Gabriela Mellado-SanchezMarcela F Pasetti
May 29, 2012·Pulmonary Pharmacology & Therapeutics·Jake K Nikota, Martin R Stämpfli
Mar 1, 2011·Microbes and Infection·Thomas R LawsRoman A Lukaszewski
Dec 25, 2015·Trends in Microbiology·Roger D PechousWilliam E Goldman
Mar 24, 2012·Journal of Medical Microbiology·E D Williamson, P C F Oyston
Nov 2, 2014·Cellular Microbiology·Peter M MerrittMelanie M Marketon
Nov 13, 2014·Frontiers in Microbiology·Miqdad O Dhariwala, Deborah M Anderson
Mar 16, 2016·Infection and Immunity·Nandakumar PackiriswamyNarayanan Parameswaran
Jan 16, 2019·Infection and Immunity·Rachel M OlsonDeborah M Anderson
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Mar 5, 2020·The Journal of Infectious Diseases·Srijon K BanerjeeRoger D Pechous

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