Neutrophils as a Protagonist and Target in Chronic Rhinosinusitis

Clinical and Experimental Otorhinolaryngology
Hai WangZheng Liu

Abstract

Neutrophils have traditionally been acknowledged as the first immune cells that are recruited to inflamed tissues during acute inflammation. By contrast, their importance in the context of chronic inflammation has been studied in less depth. Neutrophils can be recruited and are largely present in the nasal mucosa of patients with chronic rhinosinusitis (CRS) both in Asians and in Caucasians. Increased infiltration of neutrophils in patients with CRS has been linked to poor corticosteroid response and disease prognosis. Meanwhile, tissue neutrophils may possess specific phenotypic features distinguishing them from resting blood counterparts and are endowed with particular functions, such as cytokines and chemokines production, thus may contribute to the pathogenesis of CRS. This review aims to summarize our current understanding of the pathophysiologic mechanisms of CRS, with a focus on the roles of neutrophils. We discuss recruitment, function, and regulation of neutrophils in CRS and outline the potential therapeutic strategies targeting neutrophils.

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Citations

Oct 3, 2019·Clinical and Experimental Otorhinolaryngology·Dae Woo Kim
Mar 7, 2020·Allergy, Asthma & Immunology Research·Gwanghui RyuJi Hun Mo
Jul 1, 2020·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Mehmet Emre SivriceVural Akın
Sep 17, 2020·Allergy, Asthma & Immunology Research·Dong Kyu KimDae Woo Kim
Dec 8, 2020·Current Opinion in Allergy and Clinical Immunology·Gwanghui RyuHyun-Woo Shin
Aug 19, 2021·Clinical and Experimental Otorhinolaryngology·Do Hyun Kim, Sung Won Kim
Sep 21, 2021·Klinicheskaia laboratornaia diagnostika·Ludmila Andreevna AschinaA V Fedin
Feb 6, 2021·Clinical and Experimental Otorhinolaryngology·Dong-Kyu KimGil Myeong Son
Dec 3, 2021·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Yin YaoZheng Liu

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Methods Mentioned

BETA
bronchoalveolar lavage
lavage

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