Neutrophils as a Therapeutic Target in Cancer

Frontiers in Immunology
Zvi Granot

Abstract

Neutrophils are the most abundant population of white blood cells in the human circulation. They are terminally differentiated myeloid cells which were traditionally associated with fighting infections and inflammatory processes. While this perception of neutrophils is still widely prevalent, in the past decade it has become clear that neutrophils also play a critical role in tumor growth and progression. The unique tumor microenvironment, consisting of the non-malignant stroma that surrounds tumor cells, is shaped by numerous cues emanating from both tumor cells and stromal cells which support the growing tumor. Various immune cells, including neutrophils, make up a significant proportion of the tumor stroma. Immune cells exist for the protection of the host against various threats including the detection and elimination of cancerous cells. However, in the context of cancer immune cells are often coerced into a tumor supportive phenotype. This is also the case for neutrophils, which are often described to possess tumor promoting properties and to associate with poorer prognosis. The fact that neutrophils may contribute to tumor growth and progression suggests they may be targets for anti-cancer therapies. This review discusses...Continue Reading

References

Aug 1, 1968·The American Journal of Physiology·P A ChervenickM M Wintrobe
Aug 18, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·N S Potter, C V Harding
Aug 16, 2002·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Rosario Alberto CarusoCosimo Inferrera
Sep 14, 2007·Immunological Reviews·William M Nauseef
Feb 13, 2008·Proceedings of the National Academy of Sciences of the United States of America·Farbod ShojaeiNapoleone Ferrara
Feb 7, 2009·Nature Reviews. Immunology·Dmitry I Gabrilovich, Srinivas Nagaraj
Apr 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cesar A CorzoDmitry I Gabrilovich
Sep 2, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hanne Krogh JensenHans von der Maase
Jun 3, 2010·The Journal of Clinical Investigation·Kyle J EashDaniel C Link
Aug 9, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Michelle D ReidVolkan Adsay
Jun 12, 2012·Journal of Leukocyte Biology·Sergey V NovitskiyHarold L Moses
Feb 7, 2014·International Journal of Cancer. Journal International Du Cancer·Inbal MishalianZvi G Fridlender
Jun 5, 2014·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Ronit Vogt SionovZvi Granot
Nov 11, 2014·The Journal of Clinical Investigation·Evgeniy B EruslanovSunil Singhal
May 20, 2015·Nature·Veronica FinisguerraMassimiliano Mazzone
Jul 2, 2015·Journal of Visualized Experiments : JoVE·Ronit Vogt SionovZvi Granot
Jul 21, 2015·Nature Medicine·Andrew J GentlesAsh A Alizadeh
Dec 10, 2015·Mediators of Inflammation·Zvi Granot, Jadwiga Jablonska
Dec 10, 2015·Nature·Stefanie K Wculek, Ilaria Malanchi
Jun 11, 2016·Nature Reviews. Cancer·Seth B CoffeltKarin E de Visser
Apr 1, 2017·Journal of Leukocyte Biology·Jadwiga Jablonska, Zvi Granot
Mar 2, 2018·Cancer Research·Maya GershkovitzZvi Granot
Feb 8, 2019·Nature·Barbara Maria SzczerbaNicola Aceto
Apr 19, 2019·Nature·Filippo VegliaDmitry I Gabrilovich

❮ Previous
Next ❯

Citations

Feb 12, 2020·The Journal of Experimental Medicine·Vasiliki KoliarakiGeorge Kollias
Dec 13, 2019·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Monique B NilssonJohn V Heymach
Aug 3, 2020·Molecular Oncology·James O JonesJacqueline D Shields
Aug 28, 2020·Oncotarget·Justyna Magdalena HermanowiczDariusz Pawlak
Apr 5, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bernardo L RapoportRonald Anderson
Aug 14, 2020·Cancers·Alessandra CaligiuriAlessandra Gentilini
Aug 15, 2020·Frontiers in Oncology·Cathelijn E M AartsTaco W Kuijpers
Jun 26, 2020·International Journal of Molecular Sciences·Pierpaolo GinefraNicola Vannini
Jan 15, 2021·Free Radical Biology & Medicine·Andrew B DasMark B Hampton
Jan 24, 2021·Molecular Therapy : the Journal of the American Society of Gene Therapy·Jing HeFucheng He
Oct 11, 2020·Current Opinion in Immunology·Andrea Rubio-PonceIván Ballesteros
Mar 6, 2021·Journal of Cellular and Molecular Medicine·Hao SuBo Feng
Mar 16, 2021·Frontiers in Immunology·Ding WangLing Zhang
Dec 2, 2020·Pharmacology & Therapeutics·Yi Xiao, Dihua Yu
May 1, 2021·Cancers·Yang ZhaoJennifer Gamble
Jun 3, 2021·The FEBS Journal·Magdalena K Sznurkowska, Nicola Aceto
Jul 3, 2021·Cancers·Besan H Al-SaafeenBasel K Al-Ramadi
Jul 13, 2021·Signal Transduction and Targeted Therapy·Huakan ZhaoYongsheng Li
Jul 7, 2021·The Journal of Clinical Investigation·Evgenii N TcyganovDmitry I Gabrilovich
Jul 8, 2021·Nature Reviews. Immunology·Catherine C Hedrick, Ilaria Malanchi
Dec 9, 2021·Journal of Cellular and Molecular Medicine·Xuming SongGaochao Dong

❮ Previous
Next ❯

Datasets Mentioned

BETA
GM-CSF

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.