Neutrophils in Cancer: Two Sides of the Same Coin

Journal of Immunology Research
Eileen Uribe-Querol, Carlos Rosales

Abstract

Neutrophils are the most abundant leukocytes in blood and are considered to be the first line of defense during inflammation and infections. In addition, neutrophils are also found infiltrating many types of tumors. Tumor-associated neutrophils (TANs) have relevant roles in malignant disease. Indeed neutrophils may be potent antitumor effector cells. However, increasing clinical evidence shows TANs correlate with poor prognosis. The tumor microenvironment controls neutrophil recruitment and in turn TANs help tumor progression. Hence, TANs can be beneficial or detrimental to the host. It is the purpose of this review to highlight these two sides of the neutrophil coin in cancer and to describe recent studies that provide some light on the mechanisms for neutrophil recruitment to the tumor, for neutrophils supporting tumor progression, and for neutrophil activation to enhance their antitumor functions.

References

Nov 15, 1988·International Journal of Cancer. Journal International Du Cancer·P A AeedD R Welch
Feb 9, 1972·Nature: New Biology·A H PickaverH Smith
Jan 1, 1995·The Journal of Experimental Medicine·L A PekarekH Schreiber
Oct 1, 1998·European Journal of Immunology·M J Martínez-LorenzoA Anel
Feb 9, 1999·Biotherapy·Y IshiharaK Matsunaga
Apr 27, 2000·Nature Cell Biology·J L BodmerJ Tschopp
Oct 12, 2000·Nature Cell Biology·G BergersD Hanahan
Dec 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·B AlmandD I Gabrilovich
Jan 4, 2001·Immunological Reviews·P ScapiniM A Cassatella
Mar 10, 2001·Laboratory Investigation; a Journal of Technical Methods and Pathology·A GrenierS Chollet-Martin
Mar 14, 2001·American Journal of Physiology. Cell Physiology·Q D WuH P Redmond
Aug 18, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·K J MalmbergR Kiessling
Oct 5, 2001·The American Journal of Pathology·E Van CoillieG Opdenakker
Feb 14, 2002·Trends in Biochemical Sciences·Jean-Luc BodmerJürg Tschopp
Aug 16, 2002·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Rosario Alberto CarusoCosimo Inferrera
Dec 10, 2002·International Journal of Cancer. Journal International Du Cancer·Helmut SchaiderMeenhard Herlyn
Jan 29, 2003·The European Journal of Surgery = Acta Chirurgica·Koji DoiKuniyoshi Tanaka
Jul 17, 2003·International Journal of Cancer. Journal International Du Cancer·Margaret J Slattery, Cheng Dong
Oct 1, 2003·Nature Genetics·Milagros BalbínCarlos López-Otín
Nov 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bernhard StockmeyerMartin Herrmann
Feb 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael P KeaneRobert M Strieter
May 18, 2004·Arthritis and Rheumatism·Andrew CrossRobert J Moots
Jul 22, 2004·Blood·Sunil S Metkar, Christopher J Froelich
Aug 7, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Joseph E De LarcoLeo T Furcht
Nov 20, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Véronique MassonAgnès Noël
Feb 3, 2005·Journal of Gastroenterology and Hepatology·Yoshihito ImaiKazuichi Okazaki
Mar 18, 2005·Annual Review of Immunology·Anthony W Segal
Aug 25, 2005·Journal of Surgical Oncology·S R WalshN J Keeling

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Citations

Apr 14, 2016·Seminars in Immunology·Katrin Moses, Sven Brandau
Aug 26, 2016·Immunological Reviews·Louise W TreffersHanke L Matlung
Aug 26, 2016·Immunological Reviews·Patrizia ScapiniMarco A Cassatella
Aug 26, 2016·Immunological Reviews·Theodore GurolQing Deng
Aug 25, 2017·Acta Oncologica·Antoine SchernbergEric Deutsch
Oct 13, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Oyeon ChoEun Ju Lee
Jun 19, 2018·Cancers·Emily Rodrigues, Matthew S Macauley
Jun 16, 2018·The FEBS Journal·Gopinath M SundaramPrabha Sampath
Mar 9, 2018·Frontiers in Physiology·Carlos Rosales
Nov 7, 2018·Disease Models & Mechanisms·Denver D BrittoJonathan W Astin
Nov 28, 2018·British Journal of Cancer·Tiziana TriulziElda Tagliabue
Apr 29, 2018·Journal of Gastrointestinal Cancer·Joey Mercier, Ioannis A Voutsadakis
Apr 24, 2019·Cancers·Lingyun WuRakesh K Singh
Oct 26, 2018·Journal of Gastrointestinal Cancer·AnnaLee PolicicchioIoannis A Voutsadakis
Mar 24, 2020·Journal of Leukocyte Biology·Carlos Rosales
Oct 4, 2017·Journal of breast cancer·Ki-Tae HwangSuzy Kim
Jul 4, 2019·Breast Cancer Research and Treatment·Jasmin ZeindlerSavas Deniz Soysal
Sep 11, 2020·The FEBS Journal·Fernanda G Kugeratski, Raghu Kalluri
Sep 29, 2020·Expert Opinion on Biological Therapy·Victor I Seledtsov, Alexei von Delwig
Apr 5, 2017·Frontiers in Immunology·Carlos Rosales
Oct 4, 2017·Science China. Life Sciences·Taojing RanLiwu Li
Sep 23, 2018·Journal of Clinical Medicine·Miao-Fen ChenPing-Tsung Chen
Dec 25, 2019·Scientific Reports·Rachel HowardKathleen M Egan

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BETA
xenografts
xenograft

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