Neutrophils in the war against Staphylococcus aureus: predator-prey models to the rescue

Journal of Dairy Science
J C Detilleux

Abstract

To address the question of whether a minimum concentration of blood neutrophils is necessary to decrease Staphylococcus aureus concentration in mastitic milk, literature was searched for studies in which neutrophils were incubated with Staph. aureus. Different mathematical models that describe the changes in Staph. aureus population as a function of neutrophilic concentrations were applied to the collected data. The best fitted model established (1) that the rate of bacterial killing depended on the ratio of neutrophils to bacteria with neutrophilic attack rate accelerating at first before decelerating as the ratio increases, and (2) that neutrophil concentration should be within a limited range to trigger a decline in the bacterial population. Outcomes of this model are supported by what is known about neutrophilic functions and laboratory findings in bovine and human neutrophils. These results may be of assistance in setting selection goals for a better resilience to Staph. aureus mastitis in dairy cattle. Indeed, an optimal neutrophilic concentration appears to exist for successful clearance of Staph. aureus infection, which is neither the lowest nor the highest one.

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Citations

Mar 24, 2012·Animal : an International Journal of Animal Bioscience·A B Doeschl-Wilson
Nov 22, 2005·Infection and Immunity·Lorena P N TuchscherrDaniel O Sordelli
Mar 3, 2011·Genetics, Selection, Evolution : GSE·J C Detilleux
May 14, 2010·PloS One·Roy MalkaVered Rom-Kedar
May 14, 2008·The Journal of Dairy Research·Johann HuberMarkus Nagl

Related Concepts

Blood Bactericidal Activity
Bos indicus
Lactation, Prolonged
Differential White Blood Cell Count Procedure
Mastitis, Bovine
Mathematics
Neutrophil Band Cells
Phagocytosis
Staphylococcal Infections
Staphylococcus aureus

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