Neutrophils in Tissue Trauma of the Skin, Bone, and Lung: Two Sides of the Same Coin

Journal of Immunology Research
A KovtunA Ignatius

Abstract

Following severe tissue injury, patients are exposed to various danger- and microbe-associated molecular patterns, which provoke a strong activation of the neutrophil defense system. Neutrophils trigger and modulate the initial posttraumatic inflammatory response and contribute critically to subsequent repair processes. However, severe trauma can affect central neutrophil functions, including circulation half-life, chemokinesis, phagocytosis, cytokine release, and respiratory burst. Alterations in neutrophil biology may contribute to trauma-associated complications, including immune suppression, sepsis, multiorgan dysfunction, and disturbed tissue regeneration. Furthermore, there is evidence that neutrophil actions depend on the quality of the initial stimulus, including trauma localization and severity, the micromilieu in the affected tissue, and the patient's overall inflammatory status. In the present review, we describe the effects of severe trauma on the neutrophil phenotype and dysfunction and the consequences for tissue repair. We particularly concentrate on the role of neutrophils in wound healing, lung injury, and bone fractures, because these are the most frequently affected tissues in severely injured patients.

References

Oct 1, 1992·Journal of Applied Physiology·H InanoC M Doerschuk
Jan 1, 1990·Archives of Orthopaedic and Trauma Surgery·B GrøgaardO Reikerås
May 1, 1990·Journal of Applied Physiology·C M DoerschukJ C Hogg
Oct 1, 1988·Journal of Applied Physiology·G P Downey, G S Worthen
Nov 1, 1986·The Journal of Clinical Investigation·R H SimonR F Todd
Aug 1, 1972·The Journal of Clinical Investigation·D M Simpson, R Ross
Oct 1, 1995·Acta Orthopaedica Scandinavica·E GöktürkZ Gülbas
Jul 1, 1995·The Journal of Investigative Dermatology·E FeikenL R Lund
Oct 1, 1994·Journal of Applied Physiology·S M ButtrumG B Nash
Sep 1, 1996·American Journal of Respiratory and Critical Care Medicine·S Chollet-MartinM A Gougerot-Pocidalo
Dec 1, 1995·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·S A AdamsE G Shephard
Jul 1, 1997·The American Journal of Physiology·C DelclauxA Harf
Sep 25, 1997·Archives of Surgery·D B AllenT K Hunt
Jul 31, 1998·The American Journal of Physiology·D CardenS Alexander
May 26, 1999·American Journal of Respiratory Cell and Molecular Biology·A J MackarelC M O'Connor
Dec 11, 1999·Archives of Surgery·M McCourtH P Redmond
Jul 6, 2000·The EMBO Journal·A O AliprantisA Zychlinsky
Nov 15, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·E AbrahamJ Arcaroli
Apr 20, 2001·Current Pharmaceutical Design·T D Penning
Apr 24, 2001·Skin Pharmacology and Applied Skin Physiology·N Z CantürkS Solakoglu
Aug 24, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·H H GinzbergG P Downey
Sep 22, 2001·Perfusion·G MatheisA Moritz
Jan 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Harald CarlsenRune Blomhoff
Apr 10, 2002·Critical Care Medicine·Elie AzoulayBenoît Schlemmer
Mar 29, 2003·Physiological Reviews·Alan R BurnsDavid C Walker
May 19, 2004·American Journal of Surgery·Julie E Park, Adrian Barbul
Jun 10, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kim Theilgaard-MönchNiels Borregaard
Jul 23, 2004·Thrombosis and Haemostasis·Julia V DoviLuisa A DiPietro
Aug 11, 2004·Burns : Journal of the International Society for Burn Injuries·Nermina JahovicBerrak C Yeğen

❮ Previous
Next ❯

Citations

Nov 6, 2018·Current Opinion in Hematology·Katja L VogtAlison M Condliffe
Jan 21, 2019·Experimental Dermatology·Markus Böhm, Thomas Luger
Mar 23, 2019·Blood·Fernanda V S Castanheira, Paul Kubes
Mar 23, 2019·Blood·Itziar CossíoAndrés Hidalgo
Jul 19, 2019·Advanced Healthcare Materials·Astrid Johanna HeckHolger Barth
Aug 25, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Melanie Haffner-LuntzerMichael Lehmicke
Jun 18, 2019·The Journal of Clinical Investigation·Moritz Peiseler, Paul Kubes
Feb 16, 2020·Scientific Reports·Derek S WhelanAnthony J P Clover
Jul 29, 2020·International Journal of Molecular Sciences·Elena GroppaSerena Zacchigna
Aug 28, 2020·APL Bioengineering·Wenzhen ZhuDong-An Wang
Apr 23, 2020·International Journal of Molecular Sciences·Elisabeth M Liebler-TenorioPetra Reinhold
Apr 25, 2019·International Journal of Molecular Sciences·Alan V Nguyen, Athena M Soulika
Sep 26, 2019·Frontiers in Immunology·Esmaeil MortazIan M Adcock
Oct 24, 2020·Advances in Wound Care·Natasha AhujaKathryn Bass
Feb 6, 2021·Pathogens·Gustavo Henrique Rodrigues Vale de MacedoLuís Cláudio Nascimento da Silva
Oct 23, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Aishwari S Kumar, Kaladhar Kamalasanan
Mar 7, 2021·Science Advances·Ajitha ThanabalasuriarAntonio DiGiandomenico
Mar 7, 2021·International Journal of Molecular Sciences·Li HaoLixin Liu
Apr 3, 2021·Frontiers in Cellular and Infection Microbiology·Hisanori Domon, Yutaka Terao
May 11, 2021·Frontiers in Cellular Neuroscience·Sandra ZivkovicYi Ren
May 15, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jorge A Masso-SilvaLaura E Crotty Alexander

❮ Previous
Next ❯

Methods Mentioned

BETA
bronchoalveolar lavage

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Related Papers

Health Services Journal
Ingrid Torjesen
Singapore Medical Journal
Weekitt Kittisupamongkol
WMJ : Official Publication of the State Medical Society of Wisconsin
Barry Blackwell
Nature Genetics
Andrea Gallavotti, Robert J Schmidt
© 2022 Meta ULC. All rights reserved