Neutrophils Self-Regulate Immune Complex-Mediated Cutaneous Inflammation through CXCL2

The Journal of Investigative Dermatology
Jackson LiangYao LiLai Guan Ng

Abstract

Deposition of immune complexes (ICs) in tissues triggers acute inflammatory pathology characterized by massive neutrophil influx leading to edema and hemorrhage, and is especially associated with vasculitis of the skin, but the mechanisms that regulate this type III hypersensitivity process remain poorly understood. Here, using a combination of multiphoton intravital microscopy and genomic approaches, we re-examined the cutaneous reverse passive Arthus reaction and observed that IC-activated neutrophils underwent transmigration, triggered further IC formation, and transported these ICs into the interstitium, whereas neutrophil depletion drastically reduced IC formation and ameliorated vascular leakage in vivo. Thereafter, we show that these neutrophils expressed high levels of CXCL2, which further amplified neutrophil recruitment and activation in an autocrine and/or paracrine manner. Notably, CXCL1 expression was restricted to tissue-resident cell types, but IC-activated neutrophils may also indirectly, via soluble factors, modulate macrophage CXCL1 expression. Consistent with their distinct cellular origins and localization, only neutralization of CXCL2 but not CXCL1 in the interstitium effectively reduced neutrophil recruitm...Continue Reading

Citations

May 12, 2016·Current Rheumatology Reports·Luis Arturo Gutiérrez-González
Oct 29, 2017·Scientific Reports·Huynh Thi Le DuyenKatja Fink
Jul 18, 2018·Journal of Neuroinflammation·Joshua S StoolmanBenjamin M Segal
Apr 13, 2019·Immunological Reviews·Tim Lämmermann, Wolfgang Kastenmüller
Dec 20, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Germana LentiniAngelina Midiri
May 12, 2019·Science Immunology·Yoshishige MiyabeAndrew D Luster
Nov 11, 2019·Nature Reviews. Rheumatology·Yoshishige MiyabeAndrew D Luster
Aug 26, 2016·Immunological Reviews·Krisztina Futosi, Attila Mócsai
Dec 15, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anita OroszAttila Mócsai
May 22, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Kyle T DittloffBrenda Russell
Oct 12, 2021·Frontiers in Cell and Developmental Biology·Dafeng XuJinfang Zheng
Nov 17, 2021·Investigative Ophthalmology & Visual Science·Md Huzzatul MursalinMichelle C Callegan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.