Neutrophin switching in spinal motoneurons of amyotrophic lateral sclerosis

Neuroreport
T NishioS Furukawa

Abstract

To clarify the roles of neurotrophins in the human spinal motoneurons, with special reference to amyotrophic lateral sclerosis (ALS), we studied the immunohistochemical localizations of neurotrophins and their receptors in spinal cords of patients with ALS and compared them with controls. In the controls, the majority of motoneurons showed BDNF-, NT3-, trkB- and trkC-like immunoreactivity (-LI) suggesting that the motoneurons receive an autocrine regulation by both BDNF and NT3. In ALS patients, about three-quarters of the motoneurons had degenerated and the remaining motoneurons showed significantly decreased BDNF-LI, increased NGF- and trkA-LI. These findings indicated neurotrophin-switching in the remaining spinal motoneurons of ALS patients from BDNF and NT3 responsive to NGF responsive.

References

Jul 1, 1995·Current Biology : CB·A M Davies, E M Wright
Jul 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·R C MirandaC D Toran-Allerand
Feb 1, 1997·Current Opinion in Neurobiology·A M Davies

❮ Previous
Next ❯

Citations

Dec 22, 1999·The Journal of Comparative Neurology·C R BuckT C Cope
May 8, 2013·Molecular Neurobiology·Yan-Yan HeJian-Jun Wang
Feb 12, 2000·Neuroscience Letters·I FerrerT Ribalta
Apr 6, 2005·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Yossef S LevyDaniel Offen
Jul 6, 2014·Neuroscience Letters·Jian-Dong DingLian-Shun Jia
Jan 27, 2016·Molecular Neurodegeneration·Sighild LemarchantJari Koistinaho
Jan 26, 2013·Pharmacology & Therapeutics·Shelley J AllenNikunj K Patel
Sep 21, 2004·Journal of Neuroscience Research·Bradley J TurnerSurindar S Cheema
Oct 11, 2005·Physical Medicine and Rehabilitation Clinics of North America·B Jane Distad, Michael D Weiss
Dec 6, 2016·International Journal of Molecular Sciences·Beatriz Benítez-TemiñoAngel M Pastor
May 26, 2017·Frontiers in Aging Neuroscience·Lianping XuDongsheng Fan
May 2, 2003·Journal of Neuropathology and Experimental Neurology·Alex KruttgenJoachim Weis
Jul 27, 2017·Frontiers in Neuroscience·Rosendo G HernándezBeatriz Benítez-Temiño
Nov 9, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Catarina Miranda-LourençoMaria J Diógenes

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amyloid Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is a progressive nervous system disease associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.