Nevirapine-induced stevens johnson-syndrome and fulminant hepatic failure requiring liver transplantation

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
J JaoS Huprikar

Abstract

We describe a case of nevirapine-induced Stevens-Johnson Syndrome (SJS) and fulminant hepatic failure (FHF) requiring liver transplantation. Five weeks prior to admission, a 57-year-old female with HIV infection had been switched to a nevirapine-based regimen of highly active antiretroviral therapy (HAART) with a CD4 cell count of 695/mm(3). Examination of the explanted native liver at initial transplantation revealed massive hepatic necrosis consistent with drug-induced liver injury. Primary graft nonfunction complicated the early postoperative course and liver retransplantation was required. On follow-up 2 years later, she remains in good health with an undetectable viral load on an efavirenz-based regimen of HAART. To our knowledge, this is the first report of successful liver transplantation following SJS and FHF.

References

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Citations

Oct 7, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Harshad DevarbhaviMallikarjun Patil
Jun 19, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M GastacaUNKNOWN FIPSE OLT-HIV investigators
Jun 15, 2013·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Ahmed M ElsharkawySteven Masson
Jun 12, 2018·Pediatrics International : Official Journal of the Japan Pediatric Society·Satoshi SatoYutaka Kawano
Dec 6, 2018·Liver International : Official Journal of the International Association for the Study of the Liver·Harshad Devarbhavi, Sujata Raj
Sep 28, 2013·World Journal of Hepatology·Francisco Igor Macedo
Sep 23, 2020·Annual Review of Pharmacology and Toxicology·Zaikuan J YuNamandjé N Bumpus
May 22, 2021·The Journal of Dermatology·Michiru TotsukaMichiko Aihara
May 13, 2011·Current Opinion in Organ Transplantation

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