Nevus-cell aggregates in lymph nodes: fine-needle aspiration cytologic findings and resulting diagnostic difficulties

Diagnostic Cytopathology
Paul Zaharopoulos, S David Hudnall

Abstract

We report a case of nodal nevus present in enlarged lymph nodes with changes of dermatopathic lymphadenopathy sampled by fine-needle aspiration (FNA) cytology prior to clinical evaluation of the patient. This lymph node pathology was established later by lymph node excisional biopsy, by which along with a skin biopsy the dermatopathic lymphadenopathy was tentatively attributed to early mycosis fungoides. The FNA revealed fairly atypical melanotic tissue from the dermatopathic lymphadenopathy along with nodules of uniform melanocytic nevoid cells, the presence of which in combination with the dermatopathic atypical tissue provided a tentative diagnosis of metastatic melanoma of unknown primary, with the diagnosis of nodal nevus presented as a less likely possibility. This is to our knowledge the first cytologic report on FNA of nodal nevus, which besides presenting cytologic findings of this entity highlights some of the problems related to providing an accurate diagnosis, if this exceptionally unusual pathologic entity is encountered in lymph nodes sampled for enlargement from pathologies unrelated to this entity. The subject of nevus changes in lymph nodes is briefly discussed.

References

Aug 19, 1976·Virchows Archiv. A, Pathological Anatomy and Histology·F W van den BergK Lennert
Apr 1, 1990·The Journal of Dermatology·M KatsumataK Ezoe
Feb 1, 1988·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·P Bichel, J Ornsholt
Feb 1, 1987·The American Journal of Surgical Pathology·B V ShenoyS P Benjamin
Oct 1, 1974·Pathology·S W McCarthyE Hirst
Dec 1, 1984·The American Journal of Surgical Pathology·J I EpsteinP P Rosen
Jul 1, 1981·Histopathology·R L Goldman
Oct 1, 1994·Annals of Plastic Surgery·A BortolaniG Scomazzoni
Jul 1, 1996·The American Journal of Surgical Pathology·K F CarsonA J Cochran
Apr 30, 2003·The American Journal of Surgical Pathology·David A BiddleVictor G Prieto

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Citations

Feb 22, 2012·Diagnostic Cytopathology·Sara E MonacoLiron Pantanowitz
May 28, 2010·Journal of Cutaneous Pathology·Alistair J CochranDonald L Morton
Sep 30, 2006·Pathology·Surendra Kumar Verma, Nilotpal Chowdhury
Mar 18, 2010·European Journal of Plastic Surgery·Christopher VanisonAnanth S Murthy

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