New 3-O-acyl betulinic acids from Strychnos vanprukii Craib

Journal of Natural Products
Quyet Chien NguyenGhee T Tan

Abstract

Three new betulinic acid derivatives, 3beta-O-trans-feruloylbetulinic acid (1), 3beta-O-cis-feruloylbetulinic acid (2), and 3beta-O-cis-coumaroylbetulinic acid (4), along with two known triterpenes, 3beta-O-trans-coumaroylbetulinic acid (3) and ursolic acid (6) were isolated from the leaves and twigs of Strychnos vanprukiiCraib. All isolates showed moderate anti-HIV activity with IC50 values ranging from 3 to 7 microg/mL (5 to 15 microM) in an indicator cell line for HIV infectivity. The structures of the new isolates were elucidated by spectroscopic techniques including 1D and 2D NMR spectroscopy. In addition, the structure of 1 was confirmed by X-ray crystallography.

Citations

Mar 29, 2007·Natural Product Reports·Joseph D Connolly, Robert A Hill
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Jul 16, 2010·Journal of Asian Natural Products Research·Xia-Chang WangLi-Hong Hu
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Mar 1, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Marcin BroniatowskiPaweł Wydro
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