PMID: 6989378Feb 15, 1980Paper

New 5'-sulfurated nucleosides as inhibitors of the biosynthesis of polyamines

Bollettino della Società italiana di biologia sperimentale
G CacciapuotiM Cartenì-Farina


The inhibitory effect of the deaminated analogs of S-adenosyl(5')-3-methylthiopropylamine on spermidine synthase (EC from E. coli, AdoMet decarboxylase (EC from human placenta and E. coli and AdoMet lyase (EC 3.3.1.-) from rat liver have been reported. 5'-isobutylthioadenosine, a new powerful antiproliferative drug has been assayed as substrate of MTA phosphorylase (EC The apparent Km is 1,8x10(-5) M. The inhibitory effect of 5'-isobutylthiadenosine on AdoMet lyase and spermidine synthase was also demonstrated.

Related Concepts

Alkalescens-Dispar Group
Spermidine Synthase

Related Feeds

Biosynthetic Transformations

Biosyntheic transformtions are multi-step, enzyme-catalyzed processes where substrates are converted into more complex products in living organisms. Simple compounds are modified, converted into other compounds, or joined together to form macromolecules. Discover the latest research on biosynthetic transformations here.