New adhesin functions of surface-exposed pneumococcal proteins.

BMC Microbiology
Cecile FroletAnne Marie di Guilmi

Abstract

Streptococcus pneumoniae is a widely distributed commensal Gram-positive bacteria of the upper respiratory tract. Pneumococcal colonization can progress to invasive disease, and thus become lethal, reason why antibiotics and vaccines are designed to limit the dramatic effects of the bacteria in such cases. As a consequence, pneumococcus has developed efficient antibiotic resistance, and the use of vaccines covering a limited number of serotypes such as Pneumovax and Prevnar results in the expansion of non-covered serotypes. Pneumococcal surface proteins represent challenging candidates for the development of new therapeutic targets against the bacteria. Despite the number of described virulence factors, we believe that the majority of them remain to be characterized. This is the reason why pneumococcus invasion processes are still largely unknown. Availability of genome sequences facilitated the identification of pneumococcal surface proteins bearing characteristic motifs such as choline-binding proteins (Cbp) and peptidoglycan binding (LPXTG) proteins. We designed a medium throughput approach to systematically test for interactions between these pneumococcal surface proteins and host proteins (extracellular matrix proteins, ci...Continue Reading

References

Jun 1, 1992·Zentralblatt Für Bakteriologie : International Journal of Medical Microbiology·M Kostrzynska, T Wadström
Jul 24, 1992·Cell·O SchneewindV A Fischetti
Jan 1, 1990·Free Radical Research Communications·M J VasconcellesL I Gordon
Oct 25, 1990·Nucleic Acids Research·C Aslanidis, P J de Jong
Mar 1, 1984·Infection and Immunity·J C PatonA Ferrante
Nov 1, 1995·Infection and Immunity·M van der FlierE I Tuomanen
Sep 1, 1993·Molecular Microbiology·B J PearceH R Masure
Sep 1, 1994·Infection and Immunity·M CámaraT J Mitchell
Apr 9, 1998·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·J L GarcíaR López
Jul 24, 1998·FEMS Microbiology Letters·A R Sánchez-BeatoJ L García
Nov 24, 1998·Infection and Immunity·A PolissiD Simon
Mar 30, 1999·Molecular Microbiology·P GarcíaJ L García
Mar 31, 2000·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·J M Bernstein, M Reddy
Sep 1, 2000·The Journal of Biological Chemistry·R JanulczykL Bjorck
Sep 19, 2000·Infection and Immunity·K K GosinkH R Masure
Sep 27, 2000·Journal of Bacteriology·D Zähner, R Hakenbeck
Apr 9, 2001·Infection and Immunity·S DaveL S McDaniel
Sep 7, 2001·Journal of Bacteriology·J HoskinsJ I Glass
Nov 6, 2001·Nature Structural Biology·C Fernández-TorneroA Romero
Sep 5, 2002·Molecular Microbiology·David L Hava, Andrew Camilli

❮ Previous
Next ❯

Citations

Feb 16, 2012·The Journal of Biological Chemistry·Peter MellrothBirgitta Henriques-Normark
Mar 22, 2012·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Alice EberhardtWaldemar Vollmer
Jul 5, 2012·Molecular Oral Microbiology·I Pérez-DoradoJ A Hermoso
Jan 5, 2011·Cellular Microbiology·J LöflingB Henriques-Normark
May 8, 2015·Environmental Microbiology Reports·Mirian DomenechErnesto García
Nov 9, 2010·Journal of Structural Biology·Yang DuYuxing Chen
Dec 24, 2011·Analytical Biochemistry·Nhat Khai BuiWaldemar Vollmer
Jun 27, 2014·The Journal of Infection·Charles Feldman, Ronald Anderson
Apr 24, 2016·The Journal of Infection·María S Escolano-MartínezAntonio J Martin-Galiano
Jun 2, 2018·Journal of Medical Microbiology·Helena ŽemličkováMatej Medvecký
Oct 26, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Emilie Vassal-StermannNicole M Thielens
Dec 25, 2016·The Journal of Biological Chemistry·Christophe MoreauAnne Marie Di Guilmi
Feb 18, 2017·Applied Biochemistry and Biotechnology·Ana Paula Corrêa ArgondizzoMarco Alberto Medeiros
Mar 14, 2019·Frontiers in Immunology·Donald N Ngwa, Alok Agrawal
Mar 5, 2021·Frontiers in Cellular and Infection Microbiology·Murtadha Q AliSven Hammerschmidt
Mar 7, 2021·Vaccines·Julio SempereFernando González-Camacho
Dec 11, 2013·International Journal of Biological Macromolecules·D S Jemima BeulinKarthe Ponnuraj
Nov 19, 2021·Frontiers in Cellular and Infection Microbiology·Murtadha Q AliSven Hammerschmidt

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA
chips
size exclusion chromatography

Software Mentioned

SMART
Robiomol

Related Concepts

Related Feeds

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Bacterial Cell Wall Structure

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.

Bacterial Cell Wall Structure (ASM)

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.