New administration model of trans-chalcone biodegradable polymers for the treatment of experimental leishmaniasis

Acta Tropica
Jose PiñeroBasilio Valladares

Abstract

The present study was designed to investigate a new administration model and the antileishmanial activity of a semi-synthetic chalcone, benzylideneacetophenone (trans-chalcone). The antileishmanial activity of this product was first tested in vitro against promastigotes of L. braziliensis, L. tropica, L. infantum and L. amazonensis. An in vivo experiment was carried out using subcutaneous administration of trans-chalcone and implants of synthetic biodegradable polymers, polylactic acid (PLA) and polylactic/glycolic acid (PLGA). This compound showed potent inhibitory effects on the growth of all Leishmania strains examinated. Subcutaneous administration of trans-chalcone at a single dose of 4 mg/kg of body weight reduced lesion development in mice infected with L. amazonensis. A similar inhibition of the lesion growth in mice treated with trans-chalcone and pentamidine was observed. PLA and PGLA implants of trans-chalcone at 4 mg/kg were administered to mice infected with L. amazonensis. PLGA implants induced a highest reduction in the lesion size (31.25%) than PLA implants (10.75%). Treatment in vitro with trans-chalcone at IC50, completely inhibited the pathogenicity of this parasite in vivo. The development of this model prov...Continue Reading

References

Aug 1, 1987·The Journal of Pharmacy and Pharmacology·C LhermP Gayral
Jan 1, 1995·Journal of Drug Targeting·M C Venier-JulienneJ P Benoit
Mar 1, 1995·Transactions of the Royal Society of Tropical Medicine and Hygiene·E RosenthalF Gambarelli
Jun 24, 1994·Science·R B GallagherP J Hines
Jan 1, 1995·Annual Review of Microbiology·P Borst, M Ouellette
Dec 1, 1995·Antimicrobial Agents and Chemotherapy·L ZhaiA Kharazmi
Jul 15, 1999·The Journal of Antimicrobial Chemotherapy·L ZhaiA Kharazmi
May 19, 2000·Antimicrobial Agents and Chemotherapy·T DeyN Ali
Mar 27, 2001·Phytotherapy Research : PTR·O Kayser, A F Kiderlen
Jun 16, 2001·Antimicrobial Agents and Chemotherapy·M ChenA Kharazmi
Aug 9, 2001·Transactions of the Royal Society of Tropical Medicine and Hygiene·P Desjeux
Apr 18, 2002·Antimicrobial Agents and Chemotherapy·Ryo-Ichi TsukiyamaMakio Kobayashi
Mar 26, 2003·Antimicrobial Agents and Chemotherapy·Fabiane LunardiAdair R S Santos
Jun 6, 2003·Bioorganic & Medicinal Chemistry·Mei LiuMei-Lin Go
Aug 26, 2003·Memórias do Instituto Oswaldo Cruz·Luciana Vignólio AlvesLeonor Laura Leon
Jun 15, 2004·Trends in Parasitology·Luis RivasJorge Alvar
Aug 26, 2004·Antimicrobial Agents and Chemotherapy·Mei-Lin GoKiaran Kirk

❮ Previous
Next ❯

Citations

Jan 9, 2007·Parasitology Research·María Gabriela Cabrera-SerraJosé E Piñero
Nov 26, 2013·Experimental Parasitology·Tatiane F P de MelloThais G V Silveira
Dec 4, 2015·Experimental Parasitology·Tatiane F P de MelloThais G V Silveira
Jan 1, 2008·Chemico-biological Interactions·Elga Heloísa AlbertonFátima Regina Mena Barreto Silva
Mar 27, 2010·Chemical Biology & Drug Design·Alireza ForoumadiAbbas Shafiee
Jun 23, 2015·Parasitology Research·Tatiane F P de MelloThais G V Silveira
Sep 20, 2008·Acta Tropica·M Gabriela Cabrera-SerraJose E Piñero
Dec 22, 2017·Antimicrobial Agents and Chemotherapy·Ariane de Jesus Sousa-BatistaBartira Rossi-Bergmann
Mar 15, 2019·Pest Management Science·Carla Díaz-TielasStephen O Duke
May 28, 2019·PLoS Neglected Tropical Diseases·Gaber El-Saber BatihaIkuo Igarashi
Apr 10, 2019·European Journal of Pharmacology·Milena Menegazzo Miranda-SaplaWander Rogerio Pavanelli

❮ Previous
Next ❯

Related Concepts