New agents in the treatment of small cell lung cancer

Chest
M Ghaemmaghami, J R Jett

Abstract

The treatment of small cell lung cancer (SCLC) has evolved significantly over the past 3 decades. Single-agent and combination chemotherapies given with radiotherapy have greatly improved response rates and median survival. Combination regimens such as cisplatin/etoposide, carboplatin/etoposide, ifosfamide/carboplatin/etoposide, cyclophosphamide/doxorubicin/vincristine, and etoposide/ifosfamide/cisplatin have all achieved good response rates. Improving long-term survival, however, has remained problematic. Treatment with biological response modifiers (interferons alpha and gamma) has not shown promise in this setting. New agents showing good preliminary single-agent activity in untreated SCLC include paclitaxel, vinorelbine, gemcitabine, topotecan, and teniposide. Results obtained with single-agent docetaxel and CPT-11 are thus far inconclusive. Studies evaluating response and survival rates of these new agents in combination with agents of known activity are underway.

References

Jan 1, 1994·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J F SmythS B Kaye
May 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E A FaylonaL H Einhorn
Feb 17, 1993·Journal of the National Cancer Institute·W J SlichenmyerS H Kaufmann
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J JassemN van Zandwijk

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Citations

Mar 29, 2001·Irish Journal of Medical Science·T M O'ConnorN Brennan
Oct 24, 2007·Apoptosis : an International Journal on Programmed Cell Death·Irina TretiakovaOliver Werz
Mar 4, 2000·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·B MennecierA Depierre
Sep 28, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Gregory A OttersonUNKNOWN Cancer and Leukemia Group B
Dec 20, 2011·Fitoterapia·Jun-Ming WangZheng-Tao Wang
Apr 28, 2004·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jae-Chul KimHak Choy

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